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peptidyl arginine deiminase 1

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2894

Nomenclature: peptidyl arginine deiminase 1

Family: 3.5.3.15 Peptidyl arginine deiminases (PADI)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 663 1p36.13 PADI1 peptidyl arginine deiminase 1
Mouse - 662 4 72.62 cM Padi1 peptidyl arginine deiminase, type I
Rat - 662 5q36 Padi1 peptidyl arginine deiminase 1
Previous and Unofficial Names Click here for help
HPAD10 | PDI1 | PDI | PAD1 | peptidyl arginine deiminase, type I | peptidyl arginine deiminase
Database Links Click here for help
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.5.3.15 protein L-arginine + H2O <=> protein L-citrulline + NH3
Description Reaction Reference
protein L-arginine + H2O <=> protein L-citrulline + NH3

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
o-F-amidine Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Irreversible inhibition 5.8 pIC50 1
pIC50 5.8 (IC50 1.4x10-6 M) [1]

References

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1. Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y et al.. (2011) The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. J Med Chem, 54 (19): 6919-35. [PMID:21882827]

How to cite this page

3.5.3.15 Peptidyl arginine deiminases (PADI): peptidyl arginine deiminase 1. Last modified on 17/10/2018. Accessed on 18/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2894.