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lymphocyte antigen 96

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2890

Nomenclature: lymphocyte antigen 96

Abbreviated Name: MD-2

Family: Lymphocyte antigens

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 160 8q21.11 LY96 lymphocyte antigen 96
Mouse - 160 1 A3 Ly96 lymphocyte antigen 96
Rat - 160 5 Ly96 lymphocyte antigen 96
Previous and Unofficial Names Click here for help
LPS co-receptor MD-2 | myeloid differentiation factor-2 | ESOP-1
Database Links Click here for help
Alphafold Q9Y6Y9 (Hs), Q9JHF9 (Mm)
ChEMBL Target CHEMBL2375202 (Hs), CHEMBL2384895 (Mm)
Ensembl Gene ENSG00000154589 (Hs), ENSMUSG00000025779 (Mm), ENSRNOG00000067966 (Rn)
Entrez Gene 23643 (Hs), 17087 (Mm), 448830 (Rn)
Human Protein Atlas ENSG00000154589 (Hs)
KEGG Gene hsa:23643 (Hs), mmu:17087 (Mm), rno:448830 (Rn)
OMIM 605243 (Hs)
Pharos Q9Y6Y9 (Hs)
RefSeq Nucleotide NM_015364 (Hs), NM_016923 (Mm), NM_001024279 (Rn)
RefSeq Protein NP_056179 (Hs), NP_058619 (Mm), NP_001019450 (Rn)
UniProtKB Q9Y6Y9 (Hs), Q9JHF9 (Mm)
Wikipedia LY96 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
L6H21 Small molecule or natural product Primary target of this compound Immunopharmacology Ligand Hs Inhibition 4.5 pKd 2
⤷ pKd 4.5 (Kd 3.3x10-5 M) [2]
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
neoceptin-3 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Binding - - 3
⤷ [3]
Immunopharmacology Comments
LY96 (MD2) is a binding partner of Toll-like receptor 4 (TLR4), required to initiate an innate immune response to bacterial lipopolysaccharide (LPS). The signaling complex also contains CD14 co-receptor [1]. LY96 is an important therapeutic target for inflammatory disorders.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 5 GO processes
GO:0001875 lipopolysaccharide immune receptor activity IDA
GO:0002224 toll-like receptor signaling pathway IDA
GO:0034142 toll-like receptor 4 signaling pathway ISS
GO:0045087 innate immune response IC
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0001875 lipopolysaccharide immune receptor activity IDA
GO:0002224 toll-like receptor signaling pathway IDA
GO:0034142 toll-like receptor 4 signaling pathway ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0032760 positive regulation of tumor necrosis factor production ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0001875 lipopolysaccharide immune receptor activity IDA
GO:0002224 toll-like receptor signaling pathway IDA
GO:0034142 toll-like receptor 4 signaling pathway ISS
General Comments
ChEMBL target CHEMBL3038513 is the complex of human LY96 and Toll-like receptor 4 (TLR4).

References

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1. Kitchens RL. (2000) Role of CD14 in cellular recognition of bacterial lipopolysaccharides. Chem Immunol, 74: 61-82. [PMID:10608082]

2. Wang Y, Shan X, Chen G, Jiang L, Wang Z, Fang Q, Liu X, Wang J, Zhang Y, Wu W et al.. (2015) MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis. Br J Pharmacol, 172 (17): 4391-405. [PMID:26076332]

3. Wang Y, Su L, Morin MD, Jones BT, Whitby LR, Surakattula MM, Huang H, Shi H, Choi JH, Wang KW et al.. (2016) TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proc Natl Acad Sci USA, 113 (7): E884-93. [PMID:26831104]

How to cite this page

Lymphocyte antigens: lymphocyte antigen 96. Last modified on 30/05/2017. Accessed on 07/06/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2890.