Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	2321	19p13.12	NOTCH3	notch receptor 3
Mouse	1	2318	17 17.37 cM	Notch3	notch 3
Rat	1	2319	7q11	Notch3	notch receptor 3

Previous and Unofficial Names

CADASIL | CASIL | IMF2 | notch 3 | Notch homolog 3 (Drosophila)

Database Links
Alphafold	Q9UM47 (Hs), Q61982 (Mm), Q9R172 (Rn)
CATH/Gene3D	1.25.40.20
ChEMBL Target	CHEMBL3407319 (Hs)
Ensembl Gene	ENSG00000074181 (Hs), ENSMUSG00000038146 (Mm), ENSRNOG00000004346 (Rn)
Entrez Gene	4854 (Hs), 18131 (Mm), 56761 (Rn)
Human Protein Atlas	ENSG00000074181 (Hs)
KEGG Gene	hsa:4854 (Hs), mmu:18131 (Mm), rno:56761 (Rn)
OMIM	600276 (Hs)
Pharos	Q9UM47 (Hs)
RefSeq Nucleotide	NM_000435 (Hs), NM_008716 (Mm), NM_020087 (Rn)
RefSeq Protein	NP_000426 (Hs), NP_064472 (Rn)
UniProtKB	Q9UM47 (Hs), Q61982 (Mm), Q9R172 (Rn)
Wikipedia	NOTCH3 (Hs)

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference tarextumab Hs Binding 9.9 pKd 1 ⤷ pKd 9.9 (Kd 1.2x10-10 M) [1]

Clinically-Relevant Mutations and Pathophysiology
Disease:  Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy; CADASIL Synonyms: Hereditary multi-infarct dementia [Orphanet: ORPHA136] OMIM: 125310 Orphanet: ORPHA136
Disease:  Lateral meningocele syndrome; LMNS OMIM: 130720 Orphanet: ORPHA2789
Disease:  Myofibromatosis, infantile, 2; IMF2 Synonyms: Infantile myofibromatosis [Orphanet: ORPHA2591] OMIM: 615293 Orphanet: ORPHA2591