Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	335	1q23.3	SLAMF7	SLAM family member 7
Mouse	1	333	1 H3	Slamf7	SLAM family member 7
Rat	1	342	13q24	Slamf7	SLAM family member 7

Previous and Unofficial Names

CRACC | CS1-L | CD2-like receptor-activating cytotoxic cells

Database Links
Alphafold	Q9NQ25 (Hs), Q8BHK6 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL3559386 (Hs)
Ensembl Gene	ENSG00000026751 (Hs), ENSMUSG00000038179 (Mm), ENSRNOG00000023209 (Rn)
Entrez Gene	57823 (Hs), 75345 (Mm), 364049 (Rn)
Human Protein Atlas	ENSG00000026751 (Hs)
KEGG Gene	hsa:57823 (Hs), mmu:75345 (Mm), rno:364049 (Rn)
OMIM	606625 (Hs)
Pharos	Q9NQ25 (Hs)
RefSeq Nucleotide	NM_021181 (Hs), NM_144539 (Mm), NM_001191550 (Rn)
RefSeq Protein	NP_067004 (Hs), NP_653122 (Mm), NP_001178479 (Rn)
UniProtKB	Q9NQ25 (Hs), Q8BHK6 (Mm)
Wikipedia	SLAMF7 (Hs)

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference elotuzumab Hs Binding 8.1 pKd 2 ⤷ pKd 8.1 (Kd 8.86x10-9 M) [2]

Immunopharmacology Comments

CS1 is a member of the signalling lymphocyte activation molecule (SLAM) receptor family. CS1 is a membrane glycoprotein primarily expressed on plasma cells. Homophilic interaction (i.e. interaction with itself) of CS1 induces B cell proliferation and autocrine cytokine secretion, thus playing a role in various immune functions. CS1 is a validated molecular target for the development of novel immunotherapeutics with the potential to treat MM, a malignant disease of plasma cells which remains incurable despite advances in treatment (such as bortezomib, lenalidomide and immunotherapies in clinical trial). Indeed, a combination therapy containing the anti-CS1 mAb elotuzumab (elotuzumab + lenalidomide + dexamethasone), was FDA approved for MM in 2015. CS1 expression is also elevated in patients with systemic lupus erythematosus (SLE) [1], suggesting that this condition may also benefit from clinical CS1-targeted inhibition.

Cell Type Associations

Immuno Cell Type:  Macrophages & monocytes Cell Ontology Term:   macrophage (CL:0000235) monocyte (CL:0000576)

Immuno Cell Type:  Natural killer cells Cell Ontology Term:   natural killer cell (CL:0000623)

Immuno Cell Type:  Dendritic cells Cell Ontology Term:   dendritic cell (CL:0000451)

Immuno Cell Type:  B cells Cell Ontology Term:   plasma cell (CL:0000786)

Immuno Cell Type:  T cells

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Cellular signalling

Immuno Process:  T cell (activation)

Immuno Process:  B cell (activation)

General Comments
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.