CD66e (CEACAM5) | CD molecules | IUPHAR Guide to IMMUNOPHARMACOLOGY

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CD66e (CEACAM5)

  Target has curated data in GtoImmuPdb

Target id: 2836

Nomenclature: CD66e (CEACAM5)

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 702 19q13.1-q13.2 CEACAM5 CEA cell adhesion molecule 5
Previous and Unofficial Names
CEA | carcinoembryonic antigen-related cell adhesion molecule 5 | carcinoembryonic antigen related cell adhesion molecule 5
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
labetuzumab Hs Binding - -
labetuzumab govitecan Hs Binding - -
Immunopharmacology Comments
CD66e is included in GtoImmuPdb because of its role in pathogen recognition.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0050900 leukocyte migration TAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0050900 leukocyte migration TAS
General Comments
CD66e (CEACAM5) is an epithelially expressed molecule required for cell adhesion, cellular migration, pathogen binding and activation of signaling pathways.
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.

How to cite this page

CD molecules: CD66e (CEACAM5). Last modified on 07/08/2019. Accessed on 18/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2836.