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egl-9 family hypoxia inducible factor 2

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Target not currently curated in GtoImmuPdb

Target id: 2832

Nomenclature: egl-9 family hypoxia inducible factor 2

Abbreviated Name: PHD1

Family: Prolyl hydroxylases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 407 19q13.2 EGLN2 egl-9 family hypoxia inducible factor 2
Mouse - 419 7 15.83 cM Egln2 egl-9 family hypoxia-inducible factor 2
Rat - 415 1q21 Egln2 egl-9 family hypoxia-inducible factor 2
Gene and Protein Information Comments
Using alternative methionine initiation codons, two isoforms of human EGLN2 have been reported , generating PHD1p40 (374 amino acids; UniProt identifier Q96KS0-2) and PHD1p43 (407 amino acids; UniProt identifier Q96KS0-1). PHD1p43 is considered the canonocal protein.
Previous and Unofficial Names Click here for help
HIF prolyl hydroxylase 1 | HIFPH1 | egl-9 family hypoxia-inducible factor 2
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 6ee [PMID: 22364528] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.7 pIC50 1
pIC50 9.7 (IC50 2x10-10 M) [1]


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1. Vachal P, Miao S, Pierce JM, Guiadeen D, Colandrea VJ, Wyvratt MJ, Salowe SP, Sonatore LM, Milligan JA, Hajdu R et al.. (2012) 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J Med Chem, 55 (7): 2945-59. [PMID:22364528]

How to cite this page

Prolyl hydroxylases: egl-9 family hypoxia inducible factor 2. Last modified on 17/07/2017. Accessed on 08/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY,