L3MBTL histone methyl-lysine binding protein 3 | Methyllysine reader proteins | IUPHAR Guide to IMMUNOPHARMACOLOGY

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L3MBTL histone methyl-lysine binding protein 3

Target not currently curated in GtoImmuPdb

Target id: 2830

Nomenclature: L3MBTL histone methyl-lysine binding protein 3

Family: Methyllysine reader proteins

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 780 6q23 L3MBTL3 L3MBTL histone methyl-lysine binding protein 3
Mouse - 883 10 A4 L3mbtl3 L3MBTL3 histone methyl-lysine binding protein
Rat - - 1p12 L3mbtl3 L3MBTL histone methyl-lysine binding protein 3
Gene and Protein Information Comments
A shorter isoform of human L3MBTL3 (isoform b, 755 amino acids; NP_001007103) is reported.
Previous and Unofficial Names
L3MBTL3 | L3MBTL3, histone methyl-lysine binding protein | l(3)mbt-like 3 (Drosophila) | lethal(3)malignant brain tumor-like protein 3 | MBT-1 | MBT1
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215
PDB Id:  4FL6
Ligand:  UNC1215
Resolution:  2.55Å
Species:  Human

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
UNC1215 Hs Agonist 6.9 pKd 1
pKd 6.9 (Kd 1.2x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0043249 erythrocyte maturation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 4 GO processes, IEA only
GO:0030099 myeloid cell differentiation IMP
click arrow to show/hide IEA associations
GO:0030225 macrophage differentiation IEA
GO:0030851 granulocyte differentiation IEA
GO:0043249 erythrocyte maturation IEA


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1. James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, MacNevin CJ, Norris JL, Sagum CA, Tempel W et al.. (2013) Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat. Chem. Biol., 9 (3): 184-91. [PMID:23292653]

How to cite this page

Methyllysine reader proteins: L3MBTL histone methyl-lysine binding protein 3. Last modified on 27/03/2019. Accessed on 23/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2830.