Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	780	6q23.1	L3MBTL3	L3MBTL histone methyl-lysine binding protein 3
Mouse	-	883	10 A4	L3mbtl3	L3MBTL3 histone methyl-lysine binding protein
Rat	-	-	1p12	L3mbtl3	L3MBTL histone methyl-lysine binding protein 3
Gene and Protein Information Comments
A shorter isoform of human L3MBTL3 (isoform b, 755 amino acids; NP_001007103) is reported.

Previous and Unofficial Names

L3MBTL3 | L3MBTL3, histone methyl-lysine binding protein | l(3)mbt-like 3 (Drosophila) | lethal(3)malignant brain tumor-like protein 3 | MBT-1 | MBT1

Database Links
Alphafold	Q96JM7 (Hs), Q8BLB7 (Mm)
ChEMBL Target	CHEMBL1287623 (Hs)
Ensembl Gene	ENSG00000198945 (Hs), ENSMUSG00000039089 (Mm), ENSRNOG00000011720 (Rn)
Entrez Gene	84456 (Hs), 237339 (Mm), 309550 (Rn)
Human Protein Atlas	ENSG00000198945 (Hs)
KEGG Gene	hsa:84456 (Hs), mmu:237339 (Mm), rno:309550 (Rn)
Pharos	Q96JM7 (Hs)
RefSeq Nucleotide	NM_001007102 (Hs), NM_032438 (Hs), NM_172787 (Mm)
RefSeq Protein	NP_115814 (Hs), NP_001007103 (Hs), NP_766375 (Mm)
UniProtKB	Q96JM7 (Hs), Q8BLB7 (Mm)
Wikipedia	L3MBTL3 (Hs)

Selected 3D Structures
	Description:  Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215 PDB Id:  4FL6 Ligand:  UNC1215 Resolution:  2.55Å Species:  Human References:

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference UNC1215 Hs Agonist 6.9 pKd 1 ⤷ pKd 6.9 (Kd 1.2x10-7 M) [1]

Immuno Process Associations

Immuno Process:  Immune regulation

Immuno Process:  Immune system development