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L3MBTL histone methyl-lysine binding protein 3

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Target not currently curated in GtoImmuPdb

Target id: 2830

Nomenclature: L3MBTL histone methyl-lysine binding protein 3

Family: Methyllysine reader proteins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 780 6q23.1 L3MBTL3 L3MBTL histone methyl-lysine binding protein 3
Mouse - 883 10 A4 L3mbtl3 L3MBTL3 histone methyl-lysine binding protein
Rat - - 1p12 L3mbtl3 L3MBTL histone methyl-lysine binding protein 3
Gene and Protein Information Comments
A shorter isoform of human L3MBTL3 (isoform b, 755 amino acids; NP_001007103) is reported.
Previous and Unofficial Names Click here for help
L3MBTL3 | L3MBTL3, histone methyl-lysine binding protein | l(3)mbt-like 3 (Drosophila) | lethal(3)malignant brain tumor-like protein 3 | MBT-1 | MBT1
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215
PDB Id:  4FL6
Ligand:  UNC1215
Resolution:  2.55Å
Species:  Human

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
UNC1215 Small molecule or natural product Primary target of this compound Ligand has a PDB structure Hs Agonist 6.9 pKd 1
pKd 6.9 (Kd 1.2x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Immune regulation
Immuno Process:  Immune system development


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1. James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, MacNevin CJ, Norris JL, Sagum CA, Tempel W et al.. (2013) Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol, 9 (3): 184-91. [PMID:23292653]

How to cite this page

Methyllysine reader proteins: L3MBTL histone methyl-lysine binding protein 3. Last modified on 27/03/2019. Accessed on 24/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,