Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	189	1p13.2	NRAS	NRAS proto-oncogene, GTPase
Mouse	-	189	3 45.25 cM	Nras	neuroblastoma ras oncogene
Rat	-	189	2q34	Nras	NRAS proto-oncogene, GTPase

Previous and Unofficial Names

N-ras | neuroblastoma ras oncogene | neuroblastoma RAS viral (v-ras) oncogene homolog | neuroblastoma RAS viral oncogene homolog | NRAS proto-oncogene, GTPase | NRAS proto-oncogene

Database Links
Alphafold	P01111 (Hs), P08556 (Mm), Q04970 (Rn)
ChEMBL Target	CHEMBL2079845 (Hs)
Ensembl Gene	ENSG00000213281 (Hs), ENSMUSG00000027852 (Mm), ENSRNOG00000023079 (Rn)
Entrez Gene	4893 (Hs), 18176 (Mm), 24605 (Rn)
Human Protein Atlas	ENSG00000213281 (Hs)
KEGG Gene	hsa:4893 (Hs), mmu:18176 (Mm), rno:24605 (Rn)
OMIM	164790 (Hs)
Pharos	P01111 (Hs)
RefSeq Nucleotide	NM_002524 (Hs), NM_010937 (Mm), NM_080766 (Rn)
RefSeq Protein	NP_002515 (Hs), NP_035067 (Mm), NP_542944 (Rn)
UniProtKB	P01111 (Hs), P08556 (Mm), Q04970 (Rn)
Wikipedia	NRAS (Hs)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference lonafarnib Hs Inhibition 8.6 pIC50 1 ⤷ pIC50 8.6 (IC50 2.8x10-9 M) [1] Description: Measuring inhibition of farnesylation of NRAS by human farnesyltransferase

Clinically-Relevant Mutations and Pathophysiology
Disease:  Colorectal cancer Disease Ontology: DOID:9256 OMIM: 114500
Disease:  Juvenile myelomonocytic leukemia; JMML Disease Ontology: DOID:0050458 OMIM: 607785 Orphanet: ORPHA86834
Disease:  Melanocytic nevus syndrome, congenital; CMNS Synonyms: Congenital melanocytic nevus [Disease Ontology: DOID:3157] Large congenital melanocytic nevus [Orphanet: ORPHA626] Disease Ontology: DOID:3157 OMIM: 137550 Orphanet: ORPHA626
Disease:  Melanosis, neurocutaneous; NCMS OMIM: 249400
Disease:  Nevus, epidermal Disease Ontology: DOID:0050532 OMIM: 162900
Disease:  Noonan syndrome 6; NS6 Synonyms: Noonan syndrome [Orphanet: ORPHA648] [Disease Ontology: DOID:3490] Disease Ontology: DOID:3490 OMIM: 613224 Orphanet: ORPHA648
Disease:  RAS-associated autoimmune leukoproliferative disorder; RALD OMIM: 614470 Orphanet: ORPHA268114
Disease:  Schimmelpenning-Feuerstein-Mims syndrome; SFM Synonyms: Linear nevus sebaceus syndrome [Orphanet: ORPHA2612] OMIM: 163200 Orphanet: ORPHA2612
Disease:  Thyroid carcinoma, follicular; FTC Synonyms: Differentiated thyroid carcinoma [Orphanet: ORPHA146] Follicular thyroid carcinoma [Disease Ontology: DOID:3962] Disease Ontology: DOID:3962 OMIM: 188470 Orphanet: ORPHA146