Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	450	16q24.3	TUBB3	tubulin beta 3 class III
Mouse	-	450	8 E1	Tubb3	tubulin, beta 3 class III
Rat	-	450	19q12	Tubb3	tubulin, beta 3 class III

Previous and Unofficial Names

FEOM3 | tubulin, beta 3 class III | tubulin

Database Links
Alphafold	Q13509 (Hs), Q9ERD7 (Mm), Q4QRB4 (Rn)
CATH/Gene3D	3.30.1330.20, 3.40.50.1440
ChEMBL Target	CHEMBL2597 (Hs)
DrugBank Target	Q13509 (Hs)
Ensembl Gene	ENSG00000258947 (Hs), ENSMUSG00000062380 (Mm), ENSRNOG00000017209 (Rn)
Entrez Gene	10381 (Hs), 22152 (Mm), 246118 (Rn)
Human Protein Atlas	ENSG00000258947 (Hs)
KEGG Gene	hsa:10381 (Hs), mmu:22152 (Mm), rno:246118 (Rn)
OMIM	602661 (Hs)
Pharos	Q13509 (Hs)
RefSeq Nucleotide	NM_006086 (Hs), NM_023279 (Mm), NM_139254 (Rn)
RefSeq Protein	NP_006077 (Hs), NP_075768 (Mm), NP_640347 (Rn)
UniProtKB	Q13509 (Hs), Q9ERD7 (Mm), Q4QRB4 (Rn)
Wikipedia	TUBB3 (Hs)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference combretastatin A4 Hs Inhibition 8.2 pIC50 1 ⤷ pIC50 8.2 (IC50 5.7x10-9 M) [1] Description: Measuring cytotoxicity in cells expressing TUBB3 using the sulforhodamine B colorimetric assay.
Inhibitor Comments
Please see the Inhibitors table on the More detailed page for TUBB, for information on approved drugs which may act via this protein.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Cortical dysplasia, complex, with other brain malformations 1; CDCBM1 Synonyms: Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation OMIM: 614039 Orphanet: ORPHA300570
Disease:  Fibrosis of extraocular muscles, congenital, 3A, with or without extraocular involvement; CFEOM3A Synonyms: Congenital fibrosis of extraocular muscles [Orphanet: ORPHA45358] OMIM: 600638 Orphanet: ORPHA45358