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Tubulins C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Tubulins are a family of intracellular proteins most commonly associated with microtubules, part of the cytoskeleton. They are exploited for therapeutic gain in cancer chemotherapy as targets for agents derived from a variety of natural products: taxanes, colchicine and vinca alkaloids. These are thought to act primarily through β-tubulin, thereby interfering with the normal processes of tubulin polymer formation and disassembly.

Targets

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Targets of relevance to immunopharmacology are highlighted in blue

tubulin alpha 1a C Show summary » More detailed page go icon to follow link

tubulin alpha 4a C Show summary » More detailed page go icon to follow link

tubulin beta class I C Show summary » More detailed page go icon to follow link

tubulin beta 3 class III C Show summary » More detailed page go icon to follow link

tubulin beta 4B class IVb C Show summary » More detailed page go icon to follow link

tubulin beta 8 class VIII C Show summary » More detailed page go icon to follow link

Further reading

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References

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How to cite this family page

Database page citation:

Tubulins. Accessed on 02/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=858.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.