CD2

Immunopharmacology Ligand Target has curated data in GtoImmuPdb

Target id: 2600

Nomenclature: CD2

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	351	1p13.1	CD2	CD2 molecule
Mouse	1	344	3 44.17 cM	Cd2	CD2 antigen
Rat	1	344	2q34	Cd2	Cd2 molecule

Database Links
Alphafold	P06729 (Hs), P08920 (Mm), P08921 (Rn)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL2040 (Hs)
DrugBank Target	P06729 (Hs)
Ensembl Gene	ENSG00000116824 (Hs), ENSMUSG00000027863 (Mm), ENSRNOG00000015821 (Rn)
Entrez Gene	914 (Hs), 12481 (Mm), 497761 (Rn)
Human Protein Atlas	ENSG00000116824 (Hs)
KEGG Gene	hsa:914 (Hs), mmu:12481 (Mm), rno:497761 (Rn)
OMIM	186990 (Hs)
Pharos	P06729 (Hs)
RefSeq Nucleotide	NM_001767 (Hs), NM_013486 (Mm), NM_012830 (Rn)
RefSeq Protein	NP_001758 (Hs), NP_038514 (Mm), NP_036962 (Rn)
UniProtKB	P06729 (Hs), P08920 (Mm), P08921 (Rn)
Wikipedia	CD2 (Hs)

Immunopharmacology Comments
CD2 is a cell surface glycoprotein expressed on most human T cells and natural killer (NK) cells [3] as well as by the majority of T cell lymphomas and leukemias. CD2 functions as a cell adhesion and co-stimulatory molecule. It is known to bind lymphocyte function-associated antigen-3 (LFA-3/CD58), a surface molecule expressed by antigen presenting cells and epithelial cells. The CD2/CD58 interaction promotes the initial stages of cell contact and facilitates T-cell receptor (TCR) triggering. CD2 is used as a specific marker for T cells and NK cells, and to distinguish B cell neoplasms from T cell lymphomas and leukemias.

Immunopharmacology Comments

CD2 is a cell surface glycoprotein expressed on most human T cells and natural killer (NK) cells [3] as well as by the majority of T cell lymphomas and leukemias. CD2 functions as a cell adhesion and co-stimulatory molecule. It is known to bind lymphocyte function-associated antigen-3 (LFA-3/CD58), a surface molecule expressed by antigen presenting cells and epithelial cells. The CD2/CD58 interaction promotes the initial stages of cell contact and facilitates T-cell receptor (TCR) triggering. CD2 is used as a specific marker for T cells and NK cells, and to distinguish B cell neoplasms from T cell lymphomas and leukemias.

Cell Type Associations

Immuno Cell Type:

B cells

Immuno Cell Type:

T cells

Immuno Cell Type:

Natural killer cells

Immuno Process Associations

Immuno Process:

Inflammation

Immuno Process:

T cell (activation)

Immuno Process:

Immune regulation

Immuno Process:

Immune system development

Immuno Process:

Cytokine production & signalling

Immuno Process:

Chemotaxis & migration

Immuno Process:

Cellular signalling

Immuno Disease Associations

Disease Name:	Psoriasis
Disease Synonyms:	no synonynms
Comment:	CD2 is the molecular target of alefacept, a drug that was approved for the treatment of moderate to severe plaque psoriasis.
Disease X-refs:	Disease Ontology: DOID:8893
References:

General Comments
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.

References

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1. da Silva AJ, Brickelmaier M, Majeau GR, Li Z, Su L, Hsu YM, Hochman PS. (2002) Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2(+) cells. J Immunol, 168 (9): 4462-71. [PMID:11970990]

2. Mitchell P. (2002) First biotech drug to treat psoriasis. Nat Biotechnol, 20 (7): 640-1. [PMID:12089534]

3. Yang JJ, Ye Y, Carroll A, Yang W, Lee HW. (2001) Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Curr Protein Pept Sci, 2 (1): 1-17. [PMID:12369898]