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CD2

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2600

Nomenclature: CD2

Family: CD molecules

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 351 1p13.1 CD2 CD2 molecule
Mouse 1 344 3 44.17 cM Cd2 CD2 antigen
Rat 1 344 2q34 Cd2 Cd2 molecule
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
CD2 is a cell surface glycoprotein expressed on most human T cells and natural killer (NK) cells [3] as well as by the majority of T cell lymphomas and leukemias. CD2 functions as a cell adhesion and co-stimulatory molecule. It is known to bind lymphocyte function-associated antigen-3 (LFA-3/CD58), a surface molecule expressed by antigen presenting cells and epithelial cells. The CD2/CD58 interaction promotes the initial stages of cell contact and facilitates T-cell receptor (TCR) triggering. CD2 is used as a specific marker for T cells and NK cells, and to distinguish B cell neoplasms from T cell lymphomas and leukemias.
Cell Type Associations
Immuno Cell Type:  B cells
Immuno Cell Type:  T cells
Immuno Cell Type:  Natural killer cells
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0030887 positive regulation of myeloid dendritic cell activation NAS
GO:0042267 natural killer cell mediated cytotoxicity IDA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0042110 T cell activation IBA
GO:0045580 regulation of T cell differentiation NAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0030887 positive regulation of myeloid dendritic cell activation NAS
GO:0045580 regulation of T cell differentiation NAS
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0045580 regulation of T cell differentiation NAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0032729 positive regulation of type II interferon production IDA
GO:0032757 positive regulation of interleukin-8 production IMP
GO:0032760 positive regulation of tumor necrosis factor production IDA
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0030101 natural killer cell activation IDA
GO:0030887 positive regulation of myeloid dendritic cell activation NAS
GO:0042110 T cell activation IBA
GO:0045580 regulation of T cell differentiation NAS
Immuno Disease Associations
Disease Name:  Psoriasis
Disease Synonyms:  no synonynms
Comment:  CD2 is the molecular target of alefacept, a drug that was approved for the treatment of moderate to severe plaque psoriasis.
Disease X-refs:  Disease Ontology: DOID:8893
References: 
General Comments
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.

References

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1. da Silva AJ, Brickelmaier M, Majeau GR, Li Z, Su L, Hsu YM, Hochman PS. (2002) Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2(+) cells. J Immunol, 168 (9): 4462-71. [PMID:11970990]

2. Mitchell P. (2002) First biotech drug to treat psoriasis. Nat Biotechnol, 20 (7): 640-1. [PMID:12089534]

3. Yang JJ, Ye Y, Carroll A, Yang W, Lee HW. (2001) Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Curr Protein Pept Sci, 2 (1): 1-17. [PMID:12369898]

How to cite this page

CD molecules: CD2. Last modified on 28/06/2022. Accessed on 30/11/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2600.