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Vesicular polyamine transporter

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2556

Nomenclature: Vesicular polyamine transporter

Abbreviated Name: VPAT

Systematic Nomenclature: SLC18B1

Family: SLC18 family of vesicular amine transporters

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 456 6q23.2 SLC18B1 solute carrier family 18 member B1
Mouse 12 459 10 A3-A4 Slc18b1 solute carrier family 18, subfamily B, member 1
Rat - - 1p12 Slc18b1 solute carrier family 18 member B1
Previous and Unofficial Names Click here for help
Solute carrier family 18 member B1 | solute carrier family 18, subfamily B, member 1 | solute carrier family 18
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC18B1 (Hs)
RESOLUTE SLC18B1 (Hs)
Other databases
Alphafold Q6NT16 (Hs), D3Z5L6 (Mm)
Ensembl Gene ENSG00000146409 (Hs), ENSMUSG00000037455 (Mm), ENSRNOG00000016371 (Rn)
Entrez Gene 116843 (Hs), 309570 (Rn)
Human Protein Atlas ENSG00000146409 (Hs)
KEGG Gene hsa:116843 (Hs), rno:309570 (Rn)
OMIM 613361 (Hs)
Pharos Q6NT16 (Hs)
RefSeq Nucleotide NM_052831 (Hs)
RefSeq Protein NP_439896 (Hs)
UniProtKB Q6NT16 (Hs), D3Z5L6 (Mm)
Wikipedia SLC18B1 (Hs)
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
spermine Hs - - 1
spermidine Hs - - 1
Immunopharmacology Comments
VPAT is expressed by mast cells and is responsible for vesicular storage of the polyamines, spermine and spermidine, in granules distinct from those containing histamine or serotonin [2]. VPAT is involved in vesicular release of these polyamines from mast cells.
Cell Type Associations
Immuno Cell Type:  Mast cells
Cell Ontology Term:   mast cell (CL:0000097)
References:  2

References

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1. Hiasa M, Miyaji T, Haruna Y, Takeuchi T, Harada Y, Moriyama S, Yamamoto A, Omote H, Moriyama Y. (2014) Identification of a mammalian vesicular polyamine transporter. Sci Rep, 4: 6836. [PMID:25355561]

2. Takeuchi T, Harada Y, Moriyama S, Furuta K, Tanaka S, Miyaji T, Omote H, Moriyama Y, Hiasa M. (2017) Vesicular Polyamine Transporter Mediates Vesicular Storage and Release of Polyamine from Mast Cells. J Biol Chem, 292 (9): 3909-3918. [PMID:28082679]

How to cite this page

SLC18 family of vesicular amine transporters: Vesicular polyamine transporter. Last modified on 09/03/2017. Accessed on 06/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2556.