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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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More detailed introduction
Lanosterol is a precursor for cholesterol, which is synthesized primarily in the liver in a pathway often described as the mevalonate or HMG-CoA reductase pathway. The first two steps (formation of acetoacetyl CoA and the mitochondrial generation of (S)-3-hydroxy-3-methylglutaryl-CoA) are also associated with oxidation of fatty acids.
acetyl-CoA acetyltransferase 1 C
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acetyl-CoA acetyltransferase 2 C
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hydroxymethylglutaryl-CoA synthase 1 C
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hydroxymethylglutaryl-CoA synthase 2 C
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hydroxymethylglutaryl-CoA reductase C
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mevalonate kinase C
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phosphomevalonate kinase C
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diphosphomevalonate decarboxylase C
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isopentenyl-diphosphate Δ-isomerase 1 C
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isopentenyl-diphosphate Δ-isomerase 2 C
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geranylgeranyl diphosphate synthase C
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farnesyl diphosphate synthase C
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squalene synthase C
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squalene monooxygenase C
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lanosterol synthase C
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Database page citation (select format):
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.