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plasminogen activator, tissue type

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Target not currently curated in GtoImmuPdb

Target id: 2392

Nomenclature: plasminogen activator, tissue type

Family: S1: Chymotrypsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 562 8p11.21 PLAT plasminogen activator, tissue type
Mouse - 559 8 11.42 cM Plat plasminogen activator, tissue
Rat - 559 16q12.5 Plat plasminogen activator, tissue type
Previous and Unofficial Names Click here for help
PATISS | tPA | plasminogen activator
Database Links Click here for help
Specialist databases
MEROPS S01.232 (Hs)
Other databases
Alphafold
BRENDA
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.68

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
Dup-714 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.2 pKi 1
pKi 8.2 (Ki 5.7x10-9 M) [1]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Hyperfibrinolysis, familial, due to increased release of tissue plasminogen activator
OMIM: 612348

References

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1. Galemmo RA Jr., Fevig JM, Carini DJ, Cacciola J, Wells BL, Hillyer GL, Buriak J Jr., Rossi KA, Stouten PFW, Alexander RS et al.. (1996) (N-acyl-N-alkyl)glycyl borolysine analogs: A new class of potent thrombin inhibitors. Bioorg Med Chem Lett, 6 (24): 2913–2918.

How to cite this page

S1: Chymotrypsin: plasminogen activator, tissue type. Last modified on 29/01/2016. Accessed on 21/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2392.