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Target has curated data in GtoImmuPdb
Target id: 2348
Nomenclature: cathepsin G
Family: S1: Chymotrypsin
This target is also described as a ligand entry: cathepsin G; cathepsin G; cathepsin G
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 255 | 14q12 | CTSG | cathepsin G | |
Mouse | - | 261 | 14 28.19 cM | Ctsg | cathepsin G | |
Rat | - | 26 | 15p12 | Ctsg | cathepsin G |
Previous and Unofficial Names |
vimentin-specific protease | VSP |
Database Links | |
Specialist databases | |
MEROPS | S01.133 (Hs) |
Other databases | |
Alphafold | P08311 (Hs), P28293 (Mm), P17977 (Rn) |
BRENDA | 3.4.21.20 |
ChEMBL Target | CHEMBL4071 (Hs), CHEMBL5622 (Mm) |
Ensembl Gene | ENSG00000100448 (Hs), ENSMUSG00000040314 (Mm), ENSRNOG00000020647 (Rn) |
Entrez Gene | 1511 (Hs), 13035 (Mm), 290257 (Rn) |
Human Protein Atlas | ENSG00000100448 (Hs) |
KEGG Enzyme | 3.4.21.20 |
KEGG Gene | hsa:1511 (Hs), mmu:13035 (Mm), rno:290257 (Rn) |
OMIM | 116830 (Hs) |
Pharos | P08311 (Hs) |
RefSeq Nucleotide | NM_001911 (Hs), NM_007800 (Mm), NM_001106041 (Rn) |
RefSeq Protein | NP_001902 (Hs), NP_031826 (Mm), NP_001099511 (Rn) |
UniProtKB | P08311 (Hs), P28293 (Mm), P17977 (Rn) |
Wikipedia | CTSG (Hs) |
Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
Cathepsin G is a leukocyte serine protease of the chymotrypsin family, related to neutrophil elastase and the granzymes. It is stored in azurophil granules and acts intracellularly to degrade ingested host pathogens and axtracellularly to breakdown ECM components at sites of inflammation. Cathepsin G is implicated in a number of inflammatory diseases, including chronic obstructive pulmonary disease and rheumatoid arthritis. |
Immuno Process Associations | ||
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1. Aoyama Y, Uenaka M, Konoike T, Hayasaki-Kajiwara Y, Naya N, Nakajima M. (2001) Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones. Bioorg Med Chem Lett, 11 (13): 1691-4. [PMID:11425539]
2. Méthot N, Rubin J, Guay D, Beaulieu C, Ethier D, Reddy TJ, Riendeau D, Percival MD. (2007) Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem, 282 (29): 20836-46. [PMID:17535802]
3. Santana AB, Lucas SD, Gonçalves LM, Correia HF, Cardote TA, Guedes RC, Iley J, Moreira R. (2012) N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg Med Chem Lett, 22 (12): 3993-7. [PMID:22595175]
S1: Chymotrypsin: cathepsin G. Last modified on 10/03/2020. Accessed on 02/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2348.