cathepsin G | S1: Chymotrypsin | IUPHAR Guide to IMMUNOPHARMACOLOGY

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cathepsin G

  Target has curated data in GtoImmuPdb

Target id: 2348

Nomenclature: cathepsin G

Family: S1: Chymotrypsin

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

This target is also described as a ligand entry: cathepsin Gcathepsin Gcathepsin G

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 255 14q12 CTSG cathepsin G
Mouse - 261 14 C3 Ctsg cathepsin G
Rat - 250 15p12 Ctsg cathepsin G
Previous and Unofficial Names
vimentin-specific protease | VSP
Database Links
Specialist databases
MEROPS S01.133 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 1 [PMID: 11425539] Hs Inhibition 9.4 pIC50 1
pIC50 9.4 (IC50 3.9x10-10 M) [1]
aloxistatin Hs Inhibition 6.0 pIC50 2
pIC50 6.0 (IC50 1.1x10-6 M) [2]
compound 4g [PMID: 22595175] Hs Inhibition 4.8 pIC50 3
pIC50 4.8 (IC50 1.42x10-5 M) [3]
Immunopharmacology Comments
Cathepsin G is a leukocyte serine protease of the chymotrypsin family, related to neutrophil elastase and the granzymes. It is stored in azurophil granules and acts intracellularly to degrade ingested host pathogens and axtracellularly to breakdown ECM components at sites of inflammation. Cathepsin G is implicated in a number of inflammatory diseases, including chronic obstructive pulmonary disease and rheumatoid arthritis.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0050778 positive regulation of immune response IEA


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1. Aoyama Y, Uenaka M, Konoike T, Hayasaki-Kajiwara Y, Naya N, Nakajima M. (2001) Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones. Bioorg. Med. Chem. Lett., 11 (13): 1691-4. [PMID:11425539]

2. Méthot N, Rubin J, Guay D, Beaulieu C, Ethier D, Reddy TJ, Riendeau D, Percival MD. (2007) Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J. Biol. Chem., 282 (29): 20836-46. [PMID:17535802]

3. Santana AB, Lucas SD, Gonçalves LM, Correia HF, Cardote TA, Guedes RC, Iley J, Moreira R. (2012) N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg. Med. Chem. Lett., 22 (12): 3993-7. [PMID:22595175]

How to cite this page

S1: Chymotrypsin: cathepsin G. Last modified on 10/03/2020. Accessed on 09/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY,