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cathepsin F

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Target not currently curated in GtoImmuPdb

Target id: 2347

Nomenclature: cathepsin F

Family: C1: Papain

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 484 11q13.2 CTSF cathepsin F
Mouse - 462 19 A Ctsf cathepsin F
Rat - 462 1q43 Ctsf cathepsin F
Previous and Unofficial Names Click here for help
Database Links Click here for help
Specialist databases
MEROPS C01.018 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
VBY-825 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.3 pKi 1
pKi 8.3 (Ki 4.7x10-9 M) [1]
compound (R)-26 [PMID: 22686657] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.7 pKi 2
pKi 7.7 (Ki 2.1x10-8 M) [2]
Immuno Process Associations
Immuno Process:  Antigen presentation
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Ceroid lipofuscinosis, neuronal, 13
Synonyms: CLN13 disease [Orphanet: ORPHA352709]
Neuronal ceroid lipofuscinosis [Disease Ontology: DOID:14503]
Disease Ontology: DOID:14503
OMIM: 615362
Orphanet: ORPHA352709


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1. Elie BT, Gocheva V, Shree T, Dalrymple SA, Holsinger LJ, Joyce JA. (2010) Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model. Biochimie, 92 (11): 1618-24. [PMID:20447439]

2. Frizler M, Schmitz J, Schulz-Fincke AC, Gütschow M. (2012) Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F. J Med Chem, 55 (12): 5982-6. [PMID:22686657]

How to cite this page

C1: Papain: cathepsin F. Last modified on 20/04/2020. Accessed on 23/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,