Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	484	11q13.2	CTSF	cathepsin F
Mouse	-	462	19 A	Ctsf	cathepsin F
Rat	-	462	1q43	Ctsf	cathepsin F

Previous and Unofficial Names

CATSF | CLN13

Database Links
Specialist databases
MEROPS	C01.018 (Hs)
Other databases
Alphafold	Q9UBX1 (Hs), Q9R013 (Mm)
BRENDA	3.4.22.41
ChEMBL Target	CHEMBL2517 (Hs)
Ensembl Gene	ENSG00000174080 (Hs), ENSMUSG00000083282 (Mm), ENSRNOG00000019708 (Rn)
Entrez Gene	8722 (Hs), 56464 (Mm), 361704 (Rn)
Human Protein Atlas	ENSG00000174080 (Hs)
KEGG Enzyme	3.4.22.41
KEGG Gene	hsa:8722 (Hs), mmu:56464 (Mm), rno:361704 (Rn)
OMIM	603539 (Hs)
Orphanet	ORPHA356180 (Hs)
Pharos	Q9UBX1 (Hs)
RefSeq Nucleotide	NM_003793 (Hs), NM_019861 (Mm), NM_001034110 (Rn)
RefSeq Protein	NP_003784 (Hs), NP_063914 (Mm), NP_001029282 (Rn)
UniProtKB	Q9UBX1 (Hs), Q9R013 (Mm)
Wikipedia	CTSF (Hs)

Enzyme Reaction
EC Number: 3.4.22.41

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference VBY-825 Hs Inhibition 8.3 pKi 1 ⤷ pKi 8.3 (Ki 4.7x10-9 M) [1] compound (R)-26 [PMID: 22686657] Hs Inhibition 7.7 pKi 2 ⤷ pKi 7.7 (Ki 2.1x10-8 M) [2]

Clinically-Relevant Mutations and Pathophysiology
Disease:  Ceroid lipofuscinosis, neuronal, 13 Synonyms: CLN13 disease [Orphanet: ORPHA352709] Neuronal ceroid lipofuscinosis [Disease Ontology: DOID:14503] Disease Ontology: DOID:14503 OMIM: 615362 Orphanet: ORPHA352709