complement C1r | S1: Chymotrypsin | IUPHAR Guide to IMMUNOPHARMACOLOGY

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complement C1r

  Target has curated data in GtoImmuPdb

Target id: 2334

Nomenclature: complement C1r

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 705 12p13.31 C1R complement C1r
Mouse - 707 6 F2 C1ra complement component 1, r subcomponent A
Rat - 707 4q42 C1r complement C1r
Previous and Unofficial Names
complement C1r-A subcomponent | complement component 1, r subcomponent A | complement component 1
Database Links
Specialist databases
MEROPS S01.192 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
nafamostat Hs Inhibition 4.9 pIC50 1
pIC50 4.9 (IC50 1.2x10-5 M) [1]
Immunopharmacology Comments
A protease component of the C1-complex of the classical complement pathway.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
click arrow to show/hide IEA associations
GO:0045087 innate immune response IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0006958 complement activation, classical pathway TAS
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0006958 complement activation, classical pathway TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0006956 complement activation TAS
GO:0006958 complement activation, classical pathway TAS
GO:0030449 regulation of complement activation TAS
Clinically-Relevant Mutations and Pathophysiology
Disease:  Complement component C1r/C1s deficiency
Synonyms: Immunodeficiency due to an early component of complement deficiency [Orphanet: ORPHA169147]
OMIM: 216950
Orphanet: ORPHA169147


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1. Hays SJ, Caprathe BW, Gilmore JL, Amin N, Emmerling MR, Michael W, Nadimpalli R, Nath R, Raser KJ, Stafford D et al.. (1998) 2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease. J. Med. Chem., 41 (7): 1060-7. [PMID:9544206]

How to cite this page

S1: Chymotrypsin: complement C1r. Last modified on 17/02/2017. Accessed on 05/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY,