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serine/threonine kinase 35

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Target not currently curated in GtoImmuPdb

Target id: 2222

Nomenclature: serine/threonine kinase 35

Abbreviated Name: CLIK1

Family: NKF4 family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 534 20p13 STK35 serine/threonine kinase 35
Mouse - 539 2 F1 Stk35 serine/threonine kinase 35
Rat - 604 3 q36 Stk35 serine/threonine kinase 35
Previous and Unofficial Names Click here for help
CLIK1 | CLP-36 interacting kinase | Stk35l1
Database Links Click here for help
Alphafold Q8TDR2 (Hs), Q80ZW0 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL5651 (Hs)
Ensembl Gene ENSG00000125834 (Hs), ENSMUSG00000037885 (Mm), ENSRNOG00000006002 (Rn)
Entrez Gene 140901 (Hs), 67333 (Mm), 311419 (Rn)
Human Protein Atlas ENSG00000125834 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:140901 (Hs), mmu:67333 (Mm), rno:311419 (Rn)
OMIM 609370 (Hs)
Pharos Q8TDR2 (Hs)
RefSeq Nucleotide NM_080836 (Hs), NM_183262 (Mm), NM_001107773 (Rn)
RefSeq Protein NP_543026 (Hs), NP_899085 (Mm), NP_001101243 (Rn)
UniProtKB Q8TDR2 (Hs), Q80ZW0 (Mm)
Wikipedia STK35 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: STK35
Ligand Sp. Type Action Value Parameter
bosutinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 8.7 pKd
cediranib Small molecule or natural product Hs Inhibitor Inhibition 8.3 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 8.1 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 7.8 pKd
brivanib Small molecule or natural product Hs Inhibitor Inhibition 7.6 pKd
vandetanib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 7.3 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.8 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.6 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.6 pKd
PD-173955 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.4 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

NKF4 family: serine/threonine kinase 35. Last modified on 18/08/2014. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2222.