herpes virus entry mediator | Immune checkpoint catalytic receptors | IUPHAR Guide to IMMUNOPHARMACOLOGY

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herpes virus entry mediator

  Target has curated data in GtoImmuPdb

Target id: 1887

Nomenclature: herpes virus entry mediator

Abbreviated Name: HVEM

Systematic Nomenclature: TNFRSF14

Family: Immune checkpoint catalytic receptors, Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 283 01p36.32 TNFRSF14 TNF receptor superfamily member 14
Mouse - - Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Rat - - Tnfrsf14 TNF receptor superfamily member 14
Previous and Unofficial Names
ATAR | Herpesvirus entry mediator A | HVEA | HVEM | TR2 | tumor necrosis factor receptor superfamily, member 14 | CD270 | LIGHTR | tumor necrosis factor receptor superfamily | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Natural/Endogenous Ligands
B and T lymphocyte attenuator {Sp: Human}
LIGHT {Sp: Human}
lymphotoxin-α {Sp: Human}
Adaptor proteins (Human)
TRAF2, TRAF3, TRAF5
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
B and T lymphocyte attenuator {Sp: Human} Hs - - -
lymphotoxin-α {Sp: Human} Hs - - -
LIGHT {Sp: Human} Hs - - -
Immunopharmacology Comments
HSV viral envelope glycoprotein D (gD) binds to this protein and thereby gains entry to the cell. HVEM binds to several TRAFadaptor proteins to mediate intracellular signalling and activation of the immune response.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:2000406 positive regulation of T cell migration IBA
click arrow to show/hide IEA associations
GO:0045087 innate immune response IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 4 GO processes
GO:0031295 T cell costimulation TAS
GO:0046642 negative regulation of alpha-beta T cell proliferation IBA
GO:1905675 negative regulation of adaptive immune memory response IDA
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 5 GO processes
GO:0002741 positive regulation of cytokine secretion involved in immune response IBA
GO:0031295 T cell costimulation TAS
GO:0046642 negative regulation of alpha-beta T cell proliferation IBA
GO:1905675 negative regulation of adaptive immune memory response IDA
GO:2000406 positive regulation of T cell migration IBA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0002741 positive regulation of cytokine secretion involved in immune response IBA
GO:0005031 tumor necrosis factor-activated receptor activity TAS
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 3 GO processes
GO:0031295 T cell costimulation TAS
GO:0046642 negative regulation of alpha-beta T cell proliferation IBA
GO:2000406 positive regulation of T cell migration IBA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
GO:1905675 negative regulation of adaptive immune memory response IDA
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0031295 T cell costimulation TAS
GO:0046642 negative regulation of alpha-beta T cell proliferation IBA
Immuno Process:  Barrier integrity
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0001618 virus receptor activity IEA

How to cite this page

Immune checkpoint catalytic receptors: herpes virus entry mediator. Last modified on 09/02/2018. Accessed on 16/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1887.