Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	595	01p36.22	TNFRSF8	TNF receptor superfamily member 8
Mouse	1	498		Tnfrsf8	tumor necrosis factor receptor superfamily, member 8
Rat	1	493		Tnfrsf8	TNF receptor superfamily member 8

Previous and Unofficial Names

CD30L receptor | tumor necrosis factor receptor superfamily, member 8 | tumor necrosis factor receptor superfamily

Database Links
ChEMBL Target	CHEMBL2364161 (Hs)
DrugBank Target	P28908 (Hs)
Ensembl Gene	ENSG00000120949 (Hs), ENSMUSG00000028602 (Mm), ENSRNOG00000016782 (Rn)
Entrez Gene	943 (Hs), 21941 (Mm), 25069 (Rn)
Human Protein Atlas	ENSG00000120949 (Hs)
KEGG Gene	hsa:943 (Hs), mmu:21941 (Mm), rno:25069 (Rn)
OMIM	153243 (Hs)
UniProtKB	P28908 (Hs), Q60846 (Mm), P97525 (Rn)
Wikipedia	TNFRSF8 (Hs)

Natural/Endogenous Ligands
CD30 ligand {Sp: Human}

Adaptor proteins (Human)

TRAF1, TRAF2, TRAF3, TRAF5

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Affinity Parameter Reference AFM13 Hs Binding 8.0 pKd 1 ⤷ pKd 8.0 (Kd 9.3x10-9 M) [1] Description: Binding to CD30 determined in a competition assay on KARPAS-299 cells. brentuximab vedotin Hs Inhibition - - ⤷

Other Binding Ligands
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference CD30 ligand {Sp: Human} Hs - - - ⤷

Immunopharmacology Comments

Expressed by activated T and B cells. Interacts with TRAF2 and TRAF5 to elicit downstream signalling events (NF-κB activation). CD30 may protect against autoimmunity by limiting the proliferative potential of autoreactive CD8 effector T cells. CD30 is the target of the approved anti-lymphoma monoclonal antibody drug brentuximab vedotin.

Cell Type Associations

Immuno Cell Type:  B cells Comment:  CD30 is expressed by activated, but not by resting, T and B cells.

Immuno Cell Type:  T cells Comment:  CD30 is expressed by activated, but not by resting, T and B cells.

Immuno Process Associations

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 3 GO processes GO:0033209 tumor necrosis factor-mediated signaling pathway TAS GO:0042535 positive regulation of tumor necrosis factor biosynthetic process IDA GO:0045556 positive regulation of TRAIL biosynthetic process IDA