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CD30

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1877

Nomenclature: CD30

Systematic Nomenclature: TNFRSF8

Family: Tumour necrosis factor (TNF) receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 595 1p36.22 TNFRSF8 TNF receptor superfamily member 8
Mouse 1 498 4 78.17 cM Tnfrsf8 tumor necrosis factor receptor superfamily, member 8
Rat 1 492 5q36 Tnfrsf8 TNF receptor superfamily member 8
Previous and Unofficial Names Click here for help
CD30L receptor | tumor necrosis factor receptor superfamily, member 8 | tumor necrosis factor receptor superfamily
Database Links Click here for help
Alphafold
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Natural/Endogenous Ligands Click here for help
CD30 ligand {Sp: Human}
Adaptor proteins (Human)
TRAF1, TRAF2, TRAF3, TRAF5

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Antibodies
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Antibody
Sp.
Action
Value
Parameter
Reference
AFM13 Peptide Click here for species-specific activity table Immunopharmacology Ligand Hs Binding 8.0 pKd 1
pKd 8.0 (Kd 9.3x10-9 M) [1]
Description: Binding to CD30 determined in a competition assay on KARPAS-299 cells.
brentuximab vedotin Peptide Approved drug Primary target of this compound Immunopharmacology Ligand Hs Inhibition - -
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand
Sp.
CD30 ligand {Sp: Human} Peptide Ligand is endogenous in the given species Hs - - -
Immunopharmacology Comments
Expressed by activated T and B cells. Interacts with TRAF2 and TRAF5 to elicit downstream signalling events (NF-κB activation). CD30 may protect against autoimmunity by limiting the proliferative potential of autoreactive CD8 effector T cells. CD30 is the target of the approved anti-lymphoma monoclonal antibody drug brentuximab vedotin.
Cell Type Associations
Immuno Cell Type:  B cells
Comment:  CD30 is expressed by activated, but not by resting, T and B cells.
Immuno Cell Type:  T cells
Comment:  CD30 is expressed by activated, but not by resting, T and B cells.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0032759 positive regulation of TRAIL production IDA
GO:0032760 positive regulation of tumor necrosis factor production IDA

References

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1. Reusch U, Burkhardt C, Fucek I, Le Gall F, Le Gall M, Hoffmann K, Knackmuss SH, Kiprijanov S, Little M, Zhukovsky EA. (2014) A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells. MAbs, 6 (3): 728-39. [PMID:24670809]

Contributors

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How to cite this page

MacEwan D. Tumour necrosis factor (TNF) receptor family in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F334/2023.1.