CD30 | Tumour necrosis factor (TNF) receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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CD30

  Target has curated data in GtoImmuPdb

Target id: 1877

Nomenclature: CD30

Systematic Nomenclature: TNFRSF8

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 595 01p36.22 TNFRSF8 TNF receptor superfamily member 8
Mouse 1 498 Tnfrsf8 tumor necrosis factor receptor superfamily
Rat 1 493 Tnfrsf8 TNF receptor superfamily member 8
Previous and Unofficial Names
CD30L receptor | tumor necrosis factor receptor superfamily, member 8 | tumor necrosis factor receptor superfamily
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Adaptor proteins (Human)
TRAF1, TRAF2, TRAF3, TRAF5

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Parameter Reference
AFM13 Hs Binding 8.0 pKd 1
pKd 8.0 (Kd 9.3x10-9 M) [1]
Description: Binding to CD30 determined in a competition assay on KARPAS-299 cells.
brentuximab vedotin Hs Inhibition - -
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
CD30 ligand {Sp: Human} Hs - - -
Immunopharmacology Comments
Expressed by activated T and B cells. Interacts with TRAF2 and TRAF5 to elicit downstream signalling events (NF-κB activation). CD30 may protect against autoimmunity by limiting the proliferative potential of autoreactive CD8 effector T cells. CD30 is the target of the approved anti-lymphoma monoclonal antibody drug brentuximab vedotin.
Cell Type Associations
Immuno Cell Type:  T cells
Comment:  CD30 is expressed by activated, but not by resting, T and B cells.
Immuno Cell Type:  B cells
Comment:  CD30 is expressed by activated, but not by resting, T and B cells.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0006954 inflammatory response IBA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0005031 tumor necrosis factor-activated receptor activity IBA
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process IDA
GO:0045556 positive regulation of TRAIL biosynthetic process IDA

References

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1. Reusch U, Burkhardt C, Fucek I, Le Gall F, Le Gall M, Hoffmann K, Knackmuss SH, Kiprijanov S, Little M, Zhukovsky EA. (2014) A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells. MAbs, 6 (3): 728-39. [PMID:24670809]

Contributors

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How to cite this page

David MacEwan.
Tumour necrosis factor (TNF) receptor family: CD30. Last modified on 29/08/2018. Accessed on 18/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1877.