TLR10 | Toll-like receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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TLR10

  Target has curated data in GtoImmuPdb

Target id: 1760

Nomenclature: TLR10

Family: Toll-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 792 4p14 TLR10 toll like receptor 10
Rat - - 14p11 Tlr10 toll-like receptor 10
Previous and Unofficial Names
toll-like receptor 10 | CD290 | UNQ315/PRO358
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
To date, ligands and biological functions of human TLR10 remain unclear. However, evidence suggests it plays a modulatory role with predominantly inhibitory (anti-inflammatory) effects [1].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 6 GO processes
GO:0002224 toll-like receptor signaling pathway IBA
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0006954 inflammatory response IBA
GO:0034166 toll-like receptor 10 signaling pathway TAS
click arrow to show/hide IEA associations
GO:0045087 innate immune response IEA
GO:0050729 positive regulation of inflammatory response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0002224 toll-like receptor signaling pathway IBA
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0034166 toll-like receptor 10 signaling pathway TAS
click arrow to show/hide IEA associations
GO:0050729 positive regulation of inflammatory response IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0002224 toll-like receptor signaling pathway IBA
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0034166 toll-like receptor 10 signaling pathway TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0050707 regulation of cytokine secretion IEA
Physiological Functions Comments
Detection of influenza and listeria.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Asthma, susceptibility to
Disease Ontology: DOID:2841
OMIM: 600807

References

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1. Oosting M, Cheng SC, Bolscher JM, Vestering-Stenger R, Plantinga TS, Verschueren IC, Arts P, Garritsen A, van Eenennaam H, Sturm P et al.. (2014) Human TLR10 is an anti-inflammatory pattern-recognition receptor. Proc. Natl. Acad. Sci. U.S.A., 111 (42): E4478-84. [PMID:25288745]

Contributors

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How to cite this page

Clare Bryant, Tom P. Monie.
Toll-like receptor family: TLR10. Last modified on 15/03/2017. Accessed on 22/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1760.