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TLR10

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1760

Nomenclature: TLR10

Family: Toll-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 811 4p14 TLR10 toll like receptor 10
Rat - - 14p11 Tlr10 toll-like receptor 10
Previous and Unofficial Names Click here for help
toll-like receptor 10 | CD290 | UNQ315/PRO358
Database Links Click here for help
Alphafold
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immunopharmacology Comments
To date, ligands and biological functions of human TLR10 remain unclear. However, evidence suggests it plays a modulatory role with predominantly inhibitory (anti-inflammatory) effects [1].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0006954 inflammatory response IBA
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GO:0045087 innate immune response IEA
GO:0050729 positive regulation of inflammatory response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
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GO:0050729 positive regulation of inflammatory response IEA
Physiological Functions Comments
Detection of influenza and listeria.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Asthma, susceptibility to
Disease Ontology: DOID:2841
OMIM: 600807

References

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1. Oosting M, Cheng SC, Bolscher JM, Vestering-Stenger R, Plantinga TS, Verschueren IC, Arts P, Garritsen A, van Eenennaam H, Sturm P et al.. (2014) Human TLR10 is an anti-inflammatory pattern-recognition receptor. Proc Natl Acad Sci USA, 111 (42): E4478-84. [PMID:25288745]

Contributors

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