TLR1 | Toll-like receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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TLR1

  Target has curated data in GtoImmuPdb

Target id: 1751

Nomenclature: TLR1

Family: Toll-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 762 4p14 TLR1 toll like receptor 1
Mouse - 770 5 33.53 cM Tlr1 toll-like receptor 1
Rat - - 14p11 Tlr1 toll-like receptor 1
Previous and Unofficial Names
CD281 | TIL | toll-like receptor 1 | rsc786 | TIL. LPRS5
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
TLR1/2 heterodimers detect and respond to bacterial triacyl lipopeptides [2].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 8 GO processes
GO:0002224 toll-like receptor signaling pathway IBA
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0006954 inflammatory response IBA
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway IGI
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway TAS
GO:0042116 macrophage activation NAS
click arrow to show/hide IEA associations
GO:0034130 toll-like receptor 1 signaling pathway IEA
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 5 GO processes
GO:0002224 toll-like receptor signaling pathway IBA
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway IGI
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway TAS
click arrow to show/hide IEA associations
GO:0034130 toll-like receptor 1 signaling pathway IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process ISS
GO:0045410 positive regulation of interleukin-6 biosynthetic process ISS
GO:2000484 positive regulation of interleukin-8 secretion IGI
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 6 GO processes
GO:0002224 toll-like receptor signaling pathway IBA
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway IGI
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway TAS
GO:0042116 macrophage activation NAS
click arrow to show/hide IEA associations
GO:0034130 toll-like receptor 1 signaling pathway IEA
Physiological Functions Comments
Involved in the pro-inflammatory response to bacterial lipopeptides.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Candidemia
Synonyms: Candidiasis [Disease Ontology: DOID:1508]
Disease Ontology: DOID:1508
References:  1
Disease:  Gastric cancer
Synonyms: Stomach cancer
Disease Ontology: DOID:10534
OMIM: 613659
Disease:  Leprosy, susceptibility to, 5; LPRS5
Synonyms: Leprosy [Disease Ontology: DOID:1024]
Disease Ontology: DOID:1024
OMIM: 613223
Disease:  Pancolitis
Description: A severe form of ulcerative colitis
Disease:  Prostate cancer
Disease Ontology: DOID:10283
OMIM: 176807
Disease:  Sepsis
Synonyms: Septicemia

References

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1. Plantinga TS, Johnson MD, Scott WK, van de Vosse E, Velez Edwards DR, Smith PB, Alexander BD, Yang JC, Kremer D, Laird GM et al.. (2012) Toll-like receptor 1 polymorphisms increase susceptibility to candidemia. J. Infect. Dis., 205 (6): 934-43. [PMID:22301633]

2. Uematsu S, Akira S. (2008) Toll-Like receptors (TLRs) and their ligands. Handb Exp Pharmacol, (183): 1-20. [PMID:18071652]

Contributors

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How to cite this page

Clare Bryant, Tom P. Monie.
Toll-like receptor family: TLR1. Last modified on 15/03/2017. Accessed on 22/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1751.