Top ▲

GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

TLR1

Click here for help

Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1751

Nomenclature: TLR1

Family: Toll-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 786 4p14 TLR1 toll like receptor 1
Mouse 1 795 5 33.53 cM Tlr1 toll-like receptor 1
Rat - - 14p11 Tlr1 toll-like receptor 1
Previous and Unofficial Names Click here for help
CD281 | TIL | toll-like receptor 1 | rsc786 | TIL. LPRS5
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immunopharmacology Comments
TLR1/2 heterodimers detect and respond to bacterial triacyl lipopeptides [2].
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0002224 toll-like receptor signaling pathway IDA
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway IGI
GO:0042116 macrophage activation NAS
click arrow to show/hide IEA associations
GO:0001774 microglial cell activation IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0032755 positive regulation of interleukin-6 production ISS
GO:0032757 positive regulation of interleukin-8 production IGI
GO:0032760 positive regulation of tumor necrosis factor production ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0002224 toll-like receptor signaling pathway IDA
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway IGI
Immuno Process:  Inflammation
GO Annotations:  Associated to 6 GO processes
GO:0002224 toll-like receptor signaling pathway IDA
GO:0006954 inflammatory response IBA
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway IGI
GO:0042116 macrophage activation NAS
GO:0045087 innate immune response NAS
click arrow to show/hide IEA associations
GO:0001774 microglial cell activation IEA
Physiological Functions Comments
Involved in the pro-inflammatory response to bacterial lipopeptides.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Candidemia
Synonyms: Candidiasis [Disease Ontology: DOID:1508]
Disease Ontology: DOID:1508
References:  1
Disease:  Gastric cancer
Synonyms: Stomach cancer
Disease Ontology: DOID:10534
OMIM: 613659
Disease:  Leprosy, susceptibility to, 5; LPRS5
Synonyms: Leprosy [Disease Ontology: DOID:1024]
Disease Ontology: DOID:1024
OMIM: 613223
Disease:  Pancolitis
Description: A severe form of ulcerative colitis
Disease:  Prostate cancer
Disease Ontology: DOID:10283
OMIM: 176807
Disease:  Sepsis
Synonyms: Septicemia

References

Show »

1. Plantinga TS, Johnson MD, Scott WK, van de Vosse E, Velez Edwards DR, Smith PB, Alexander BD, Yang JC, Kremer D, Laird GM et al.. (2012) Toll-like receptor 1 polymorphisms increase susceptibility to candidemia. J Infect Dis, 205 (6): 934-43. [PMID:22301633]

2. Uematsu S, Akira S. (2008) Toll-Like receptors (TLRs) and their ligands. Handb Exp Pharmacol, (183): 1-20. [PMID:18071652]

Contributors

Show »

How to cite this page