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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1751

Nomenclature: TLR1

Family: Toll-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 786 4p14 TLR1 toll like receptor 1
Mouse 1 795 5 33.53 cM Tlr1 toll-like receptor 1
Rat - - 14p11 Tlr1 toll-like receptor 1
Previous and Unofficial Names Click here for help
CD281 | TIL | toll-like receptor 1 | rsc786 | TIL. LPRS5
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
TLR1/2 heterodimers detect and respond to bacterial triacyl lipopeptides [2].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling
Physiological Functions Comments
Involved in the pro-inflammatory response to bacterial lipopeptides.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Candidemia
Synonyms: Candidiasis [Disease Ontology: DOID:1508]
Disease Ontology: DOID:1508
References:  1
Disease:  Gastric cancer
Synonyms: Stomach cancer
Disease Ontology: DOID:10534
OMIM: 613659
Disease:  Leprosy, susceptibility to, 5; LPRS5
Synonyms: Leprosy [Disease Ontology: DOID:1024]
Disease Ontology: DOID:1024
OMIM: 613223
Disease:  Pancolitis
Description: A severe form of ulcerative colitis
Disease:  Prostate cancer
Disease Ontology: DOID:10283
OMIM: 176807
Disease:  Sepsis
Synonyms: Septicemia


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1. Plantinga TS, Johnson MD, Scott WK, van de Vosse E, Velez Edwards DR, Smith PB, Alexander BD, Yang JC, Kremer D, Laird GM et al.. (2012) Toll-like receptor 1 polymorphisms increase susceptibility to candidemia. J Infect Dis, 205 (6): 934-43. [PMID:22301633]

2. Uematsu S, Akira S. (2008) Toll-Like receptors (TLRs) and their ligands. Handb Exp Pharmacol, (183): 1-20. [PMID:18071652]


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