Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	786	4p14	TLR1	toll like receptor 1
Mouse	1	795	5 33.53 cM	Tlr1	toll-like receptor 1
Rat	-	-	14p11	Tlr1	toll-like receptor 1

Previous and Unofficial Names

CD281 | TIL | toll-like receptor 1 | rsc786 | TIL. LPRS5

Database Links
Alphafold	Q15399 (Hs), Q9EPQ1 (Mm)
CATH/Gene3D	3.80.10.10, 3.40.50.10140
ChEMBL Target	CHEMBL3714412 (Hs), CHEMBL2146338 (Mm)
Ensembl Gene	ENSG00000174125 (Hs), ENSMUSG00000044827 (Mm), ENSRNOG00000038722 (Rn)
Entrez Gene	7096 (Hs), 21897 (Mm), 305354 (Rn)
Human Protein Atlas	ENSG00000174125 (Hs)
KEGG Gene	hsa:7096 (Hs), mmu:21897 (Mm), rno:305354 (Rn)
OMIM	601194 (Hs)
Pharos	Q15399 (Hs)
UniProtKB	Q15399 (Hs), Q9EPQ1 (Mm)
Wikipedia	TLR1 (Hs)

Immunopharmacology Comments

TLR1/2 heterodimers detect and respond to bacterial triacyl lipopeptides [2].

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 7 GO processes GO:0002224 toll-like receptor signaling pathway IDA GO:0006954 inflammatory response IBA GO:0034137 positive regulation of toll-like receptor 2 signaling pathway IGI GO:0042116 macrophage activation NAS GO:0045087 innate immune response IC click arrow to show/hide IEA associations GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA GO:0034130 toll-like receptor 1 signaling pathway IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 4 GO processes GO:0002224 toll-like receptor signaling pathway IDA GO:0034137 positive regulation of toll-like receptor 2 signaling pathway IGI click arrow to show/hide IEA associations GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA GO:0034130 toll-like receptor 1 signaling pathway IEA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 3 GO processes GO:0032755 positive regulation of interleukin-6 production ISS GO:0032757 positive regulation of interleukin-8 production IGI GO:0032760 positive regulation of tumor necrosis factor production ISS

Immuno Process:  Cellular signalling GO Annotations:  Associated to 5 GO processes GO:0002224 toll-like receptor signaling pathway IDA GO:0034137 positive regulation of toll-like receptor 2 signaling pathway IGI GO:0042116 macrophage activation NAS click arrow to show/hide IEA associations GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA GO:0034130 toll-like receptor 1 signaling pathway IEA

Physiological Functions Comments

Involved in the pro-inflammatory response to bacterial lipopeptides.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Candidemia Synonyms: Candidiasis [Disease Ontology: DOID:1508] Disease Ontology: DOID:1508 References:  1
Disease:  Gastric cancer Synonyms: Stomach cancer Disease Ontology: DOID:10534 OMIM: 613659
Disease:  Leprosy, susceptibility to, 5; LPRS5 Synonyms: Leprosy [Disease Ontology: DOID:1024] Disease Ontology: DOID:1024 OMIM: 613223
Disease:  Pancolitis Description: A severe form of ulcerative colitis
Disease:  Prostate cancer Disease Ontology: DOID:10283 OMIM: 176807
Disease:  Sepsis Synonyms: Septicemia