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Granulocyte colony-stimulating factor receptor

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1719

Nomenclature: Granulocyte colony-stimulating factor receptor

Family: Prolactin receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 836 1p34.3 CSF3R colony stimulating factor 3 receptor
Mouse 1 837 4 59.77 cM Csf3r colony stimulating factor 3 receptor (granulocyte)
Rat - - 5q36 Csf3r colony stimulating factor 3 receptor
Previous and Unofficial Names Click here for help
CD114 | granulocyte colony-stimulating factor receptor | GCSFR
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
Pharos
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of the human GCSF-receptor signaling complex
PDB Id:  2D9Q
Resolution:  2.8Å
Species:  Human
References:  3
Natural/Endogenous Ligands Click here for help
G-CSF {Sp: Human}

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Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
G-CSF {Sp: Human} Peptide Approved drug Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
pegfilgrastim Peptide Approved drug Primary target of this compound Hs Agonist - -
Agonist Comments
The granulocyte colony-stimulating factor receptor (CSF3R) is the primary target for the approved drugs filgrastim and pegfilgrastim.
Immunopharmacology Comments
This nuclear receptor mediates the effects of the cytokine, colony stimulating factor 3 (CSF3). CSF3 regulates the production, differentiation, and function of granulocytes.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0030593 neutrophil chemotaxis IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0045637 regulation of myeloid cell differentiation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0045637 regulation of myeloid cell differentiation IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes, IEA only
GO:0004896 cytokine receptor activity IBA
GO:0004912 interleukin-3 receptor activity IBA
GO:0019221 cytokine-mediated signaling pathway TAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0030593 neutrophil chemotaxis IEA
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Atypical chronic myeloid leukemia
Orphanet: ORPHA98824
References:  2
Disease:  Chronic neutrophilic leukemia
Orphanet: ORPHA86829
References:  1-2
Disease:  Neutrophilia, hereditary
OMIM: 162830
Orphanet: ORPHA279943
Disease:  Severe congenital neutropenia
Description: Severe congenital neutropenia (SCN) is a heterogeneous disorder of hematopoiesis. The resulting subnormal neutrophil counts lead to early onset of severe bacterial infections. SCN can be caused by mutations in several genes including ELANE, GFI1, HAX1, G6PC3, VPS45, WASP and CSF3R. SCN1 is the commonest subtype and is caused by autosomal dominant inheritance of a defective ELANE gene.
Synonyms: Kostmann syndrome
OMIM: 202700, 617014, 610738, 613107, 612541, 615285, 300299, 616022
Role: 

References

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1. Lasho TL, Mims A, Elliott MA, Finke C, Pardanani A, Tefferi A. (2014) Chronic neutrophilic leukemia with concurrent CSF3R and SETBP1 mutations: single colony clonality studies, in vitro sensitivity to JAK inhibitors and lack of treatment response to ruxolitinib. Leukemia, 28 (6): 1363-5. [PMID:24445868]

2. Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, Bottomly D, Wilmot B, McWeeney SK, Tognon CE et al.. (2013) Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med, 368 (19): 1781-90. [PMID:23656643]

3. Tamada T, Honjo E, Maeda Y, Okamoto T, Ishibashi M, Tokunaga M, Kuroki R. (2006) Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex. Proc Natl Acad Sci USA, 103 (9): 3135-40. [PMID:16492764]

How to cite this page

Prolactin receptor family: Granulocyte colony-stimulating factor receptor. Last modified on 17/10/2018. Accessed on 03/08/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1719.