Interleukin-11 receptor, α subunit | IL-6 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Interleukin-11 receptor, α subunit

  Target has curated data in GtoImmuPdb

Target id: 1709

Nomenclature: Interleukin-11 receptor, α subunit

Family: IL-6 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
Interleukin-11 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 422 9p13 IL11RA interleukin 11 receptor subunit alpha
Mouse 1 432 4 21.94 cM Il11ra1 interleukin 11 receptor, alpha chain 1
Rat 1 431 5q22 Il11ra1 interleukin 11 receptor subunit alpha 1
Previous and Unofficial Names
Il11ra | NR1 | interleukin 11 receptor, alpha | interleukin 11 receptor
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Agonist Comments
Interleukin-11 receptor, α subunit is the primary target of the approved drug oprelvekin, a recombinant form of IL-11.
Immunopharmacology Comments
This is the ligand-binding component of the functional receptor for interleukin 11.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes, IEA only
GO:0004896 cytokine receptor activity IBA
GO:0004921 interleukin-11 receptor activity IBA
GO:0019221 cytokine-mediated signaling pathway TAS
Clinically-Relevant Mutations and Pathophysiology
Disease:  Craniosynostosis and dental anomalies
OMIM: 614188
Orphanet: ORPHA284149

How to cite this page

IL-6 receptor family: Interleukin-11 receptor, α subunit. Last modified on 07/04/2017. Accessed on 17/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY,