Interleukin 3 receptor, α subunit | IL-3 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Interleukin 3 receptor, α subunit

  Target has curated data in GtoImmuPdb

Target id: 1705

Nomenclature: Interleukin 3 receptor, α subunit

Family: IL-3 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
Interleukin-3 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 378 Xp22.3 and Yp13.3 IL3RA interleukin 3 receptor subunit alpha
Mouse 1 396 Il3ra interleukin 3 receptor
Rat - - Il3ra interleukin 3 receptor subunit alpha
Previous and Unofficial Names
CD123 | cytokine receptor-like protein CYRL | SUT-1 | interleukin 3 receptor, alpha (low affinity) | interleukin 3 receptor
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
IL-3 {Sp: Human} Hs Agonist - -
Immunopharmacology Comments
This is the ligand binding subunit of the functional IL-3 receptor complex.
An anti-IL3RA antibody drug conjugate, IMGN632, is being developed by ImmunoGen for potential utility in the treatment of IL3RA (CD123) positive hematological malignancies [1,3] (see Phase 1 clinical trial NCT03386513). IMGN632 was granted FDA orphan drug designation for AML in October 2018 [2].
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0004912 interleukin-3 receptor activity TAS
GO:0019221 cytokine-mediated signaling pathway TAS

References

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1. Angelova E, Audette C, Kovtun Y, Daver N, Wang SA, Pierce S, Konoplev SN, Khogeer H, Jorgensen JL, Konopleva M et al.. (2018) CD123 expression patterns and selective targeting with a CD123-specific antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia. Haematologica, [Epub ahead of print]. [PMID:30361418]

2. FDA. Indolino-benzodiazepine compound (sulfonated DGN549-C) conjugated to the humanized anti-CD123 monoclonal antibody (G4723A). Accessed on 13/11/2018. Modified on 13/11/2018. www.accessdata.fda.gov, https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=654018

3. Kovtun Y, Jones GE, Adams S, Harvey L, Audette CA, Wilhelm A, Bai C, Rui L, Laleau R, Liu F et al.. (2018) A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells. Blood Adv, 2 (8): 848-858. [PMID:29661755]

How to cite this page

IL-3 receptor family: Interleukin 3 receptor, α subunit. Last modified on 13/11/2018. Accessed on 19/03/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1705.