Top ▲

MMP7

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 1631

Nomenclature: MMP7

Family: M10: Matrix metallopeptidase

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 267 11q22.2 MMP7 matrix metallopeptidase 7
Mouse - 264 9 2.46 cM Mmp7 matrix metallopeptidase 7
Rat - 267 8q11 Mmp7 matrix metallopeptidase 7
Previous and Unofficial Names Click here for help
matrin | PUMP-1 protease | uterine metalloproteinase | MPMM | MAT | MPSL1 | matrix metallopeptidase 7 (matrilysin, uterine)
Database Links Click here for help
Specialist databases
MEROPS M10.008 (Hs)
Other databases
Alphafold P09237 (Hs), Q10738 (Mm), P50280 (Rn)
BRENDA 3.4.24.23
CATH/Gene3D 3.40.390.10
ChEMBL Target CHEMBL4073 (Hs)
DrugBank Target P09237 (Hs)
Ensembl Gene ENSG00000137673 (Hs), ENSMUSG00000018623 (Mm), ENSRNOG00000010507 (Rn)
Entrez Gene 4316 (Hs), 17393 (Mm), 25335 (Rn)
Human Protein Atlas ENSG00000137673 (Hs)
KEGG Enzyme 3.4.24.23
KEGG Gene hsa:4316 (Hs), mmu:17393 (Mm), rno:25335 (Rn)
OMIM 178990 (Hs)
Pharos P09237 (Hs)
RefSeq Nucleotide NM_002423 (Hs), NM_010810 (Mm), NM_012864 (Rn)
RefSeq Protein NP_002414 (Hs), NP_034940 (Mm), NP_036996 (Rn)
UniProtKB P09237 (Hs), Q10738 (Mm), P50280 (Rn)
Wikipedia MMP7 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.24.23

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
doxycycline Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Guide to Malaria Pharmacology Ligand Hs Inhibition 4.1 pKd 2
⤷ pKd 4.1 (Kd 7.3x10-5 M) [2]
SL422 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.1 pKi 5
⤷ pKi 9.1 (Ki 8x10-10 M) [5]
RS 39066 Small molecule or natural product Primary target of this compound Hs Inhibition 9.6 pIC50 1
⤷ pIC50 9.6 (IC50 2.3x10-10 M) [1]
ilomastat Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.3 pIC50 4
⤷ pIC50 8.3 (IC50 5.1x10-9 M) [4]
marimastat Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.8 pIC50 3
⤷ pIC50 7.8 (IC50 1.6x10-8 M) [3]
Inhibitor Comments
SL422 is a broad-spectrum inhibitor of MMP enzymes [5].

References

Show »

1. Chen JJ, Zhang Y, Hammond S, Dewdney N, Ho T, Lin X, Browner MF, Castelhano AL. (1996) Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P2′-P3′ amide bond isostere. Bioorg Med Chem Lett, 6: 1601-1606.

2. García RA, Pantazatos DP, Gessner CR, Go KV, Woods Jr VL, Villarreal FJ. (2005) Molecular interactions between matrilysin and the matrix metalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry. Mol Pharmacol, 67 (4): 1128-36. [PMID:15665254]

3. Rasmussen HS, McCann PP. (1997) Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol Ther, 75 (1): 69-75. [PMID:9364582]

4. Takeuchi T, Hayashi M, Tamita T, Nomura Y, Kojima N, Mitani A, Takeda T, Hitaka K, Kato Y, Kamitani M et al.. (2022) Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. J Med Chem, 65 (12): 8493-8510. [PMID:35687819]

5. Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL et al.. (2001) Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem, 44 (16): 2636-60. [PMID:11472217]

How to cite this page

M10: Matrix metallopeptidase: MMP7. Last modified on 12/07/2022. Accessed on 14/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1631.