Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	416	1p36.21	CASP9	caspase 9
Mouse	-	454	4 E1	Casp9	caspase 9
Rat	-	454	5q36	Casp9	caspase 9

Previous and Unofficial Names

APAF-3 | apoptotic protease Mch-6 | ICE-LAP6 | ICE-like apoptotic protease 6 | protein phosphatase 1, regulatory subunit 56 | apoptotic protease activating factor 3 | MCH6 | PPP1R56

Database Links
Specialist databases
MEROPS	C14.010 (Hs)
Other databases
Alphafold	P55211 (Hs), Q8C3Q9 (Mm), Q9JHK1 (Rn)
BRENDA	3.4.22.62
ChEMBL Target	CHEMBL2273 (Hs)
Ensembl Gene	ENSG00000132906 (Hs), ENSMUSG00000028914 (Mm), ENSRNOG00000012944 (Rn)
Entrez Gene	842 (Hs), 12371 (Mm), 58918 (Rn)
Human Protein Atlas	ENSG00000132906 (Hs)
KEGG Enzyme	3.4.22.62
KEGG Gene	hsa:842 (Hs), mmu:12371 (Mm), rno:58918 (Rn)
OMIM	602234 (Hs)
Pharos	P55211 (Hs)
RefSeq Nucleotide	NM_032996 (Hs), NM_001229 (Hs), NM_015733 (Mm), NM_031632 (Rn)
RefSeq Protein	NP_001220 (Hs), NP_127463 (Hs), NP_056548 (Mm), NP_113820 (Rn)
UniProtKB	P55211 (Hs), Q8C3Q9 (Mm), Q9JHK1 (Rn)
Wikipedia	CASP9 (Hs)

Enzyme Reaction
EC Number: 3.4.22.62

Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference caspase 9 Hs - - PARP Hs - - pro-caspase 3 Hs - - pro-caspase 6 Hs - - pro-caspase 7 Hs - -

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference isatin sulfonamide 34 [PMID: 11384246] Hs Inhibition 6.9 pKi 1 ⤷ pKi 6.9 (Ki 1.2x10-7 M) [1] Z-LEHD-FMK Hs Inhibition - - 2 ⤷ [2]