Caspase 5 | C14: Caspase | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Caspase 5

  Target has curated data in GtoImmuPdb

Target id: 1621

Nomenclature: Caspase 5

Family: C14: Caspase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 434 11q22.2-q22.3 CASP5 caspase 5
Previous and Unofficial Names
ICH-3 protease | TY protease | ICE(rel)III | caspase 5, apoptosis-related cysteine peptidase
Database Links
Specialist databases
MEROPS C14.008 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.22.58

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
M826 Hs Inhibition 6.7 pIC50 2
pIC50 6.7 (IC50 2x10-7 M) [2]
uracil 20 Hs Inhibition 5.5 pIC50 1
pIC50 5.5 (IC50 2.98x10-6 M) [1]
Description: IC50 in a biochemical assay.
Z-WEHD-FMK Hs Inhibition - - 3
[3]
Immunopharmacology Comments
Recognition of cytoplasmic lipopolysaccharide (LPS) by Inflammatory caspases including caspases-4 and -5 leads to pyroptosis and secretion of inflammatory mediators [4-5].
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0050727 regulation of inflammatory response IBA
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0050727 regulation of inflammatory response IBA

References

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1. Fournier JF, Clary L, Chambon S, Dumais L, Harris CS, Millois C, Pierre R, Talano S, Thoreau É, Aubert J et al.. (2018) Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne. J. Med. Chem., 61 (9): 4030-4051. [PMID:29648825]

2. Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J et al.. (2005) Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg. Med. Chem. Lett., 15 (4): 1173-80. [PMID:15686936]

3. Naito T, Yokogawa T, Kim HS, Futagami M, Wataya Y, Matsuda A, Fukushima M, Kitade Y, Sasaki T. (2002) Anticancer mechanisms of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl) cytosine (ECyd, TAS-106). Nucleic Acids Res. Suppl., (2): 241-2. [PMID:12903195]

4. Shi J, Gao W, Shao F. (2017) Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death. Trends Biochem. Sci., 42 (4): 245-254. [PMID:27932073]

5. Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, Hu L, Shao F. (2014) Inflammatory caspases are innate immune receptors for intracellular LPS. Nature, 514 (7521): 187-92. [PMID:25119034]

How to cite this page

C14: Caspase: Caspase 5. Last modified on 11/02/2019. Accessed on 04/08/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1621.