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IP3 kinase B

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1448

Nomenclature: IP3 kinase B

Family: Inositol 1,4,5-trisphosphate 3-kinases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 946 1q42.12 ITPKB inositol-trisphosphate 3-kinase B
Mouse - - Itpkb inositol 1,4,5-trisphosphate 3-kinase B
Rat - 934 13q26 Itpkb inositol-trisphosphate 3-kinase B
Previous and Unofficial Names Click here for help
IP3-3KB | IP3KB | inositol 1,4,5-trisphosphate 3-kinase B | insP 3-kinase B | inositol 1
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GNF362 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 8.1 pIC50 1
pIC50 8.1 (IC50 9x10-9 M) [1]
Immunopharmacology Comments
IP3 kinase B (ITPKB) as an essential mediator of T cell activation, whose inhibition is considered a novel approach to treat autoimmune disease [1]. ITPKB inhibition blocks T-cell dependent antibody responses in vivo. GNF362 is a non-selective inhibitor of all three of the IP3 kinases in the family to which ITPKB belongs.
Immuno Process Associations
Immuno Process:  T cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cellular signalling


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1. Miller AT, Dahlberg C, Sandberg ML, Wen BG, Beisner DR, Hoerter JA, Parker A, Schmedt C, Stinson M, Avis J et al.. (2015) Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease. PLoS ONE, 10 (6): e0131071. [PMID:26121493]

How to cite this page

Inositol 1,4,5-trisphosphate 3-kinases: IP3 kinase B. Last modified on 20/04/2017. Accessed on 30/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,