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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 946 | 1q42.12 | ITPKB | inositol-trisphosphate 3-kinase B | |
Mouse | - | - | Itpkb | inositol 1,4,5-trisphosphate 3-kinase B | ||
Rat | - | 934 | 13q26 | Itpkb | inositol-trisphosphate 3-kinase B |
Previous and Unofficial Names |
IP3-3KB | IP3KB | inositol 1,4,5-trisphosphate 3-kinase B | insP 3-kinase B | inositol 1 |
Database Links | |
Alphafold | P27987 (Hs), P42335 (Rn) |
BRENDA | 2.7.1.127 |
ChEMBL Target | CHEMBL5165 (Hs) |
Ensembl Gene | ENSG00000143772 (Hs), ENSMUSG00000038855 (Mm), ENSRNOG00000002969 (Rn) |
Entrez Gene | 3707 (Hs), 320404 (Mm), 54260 (Rn) |
Human Protein Atlas | ENSG00000143772 (Hs) |
KEGG Enzyme | 2.7.1.127 |
KEGG Gene | hsa:3707 (Hs), mmu:320404 (Mm), rno:54260 (Rn) |
OMIM | 147522 (Hs) |
Pharos | P27987 (Hs) |
UniProtKB | P27987 (Hs), P42335 (Rn) |
Wikipedia | ITPKB (Hs) |
Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
IP3 kinase B (ITPKB) as an essential mediator of T cell activation, whose inhibition is considered a novel approach to treat autoimmune disease [1]. ITPKB inhibition blocks T-cell dependent antibody responses in vivo. GNF362 is a non-selective inhibitor of all three of the IP3 kinases in the family to which ITPKB belongs. |
Immuno Process Associations | ||
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1. Miller AT, Dahlberg C, Sandberg ML, Wen BG, Beisner DR, Hoerter JA, Parker A, Schmedt C, Stinson M, Avis J et al.. (2015) Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease. PLoS ONE, 10 (6): e0131071. [PMID:26121493]
Inositol 1,4,5-trisphosphate 3-kinases: IP3 kinase B. Last modified on 20/04/2017. Accessed on 02/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1448.