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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 461 | 2p25.1 | ODC1 | ornithine decarboxylase 1 | |
Mouse | - | 461 | 12 8.11 cM | Odc1 | ornithine decarboxylase, structural 1 | |
Rat | - | 461 | 6q16 | Odc1 | ornithine decarboxylase 1 |
Previous and Unofficial Names |
ODC | RNODC | ornithine decarboxylase, structural 1 |
Database Links | |
Alphafold | P11926 (Hs), P00860 (Mm), P09057 (Rn) |
BRENDA | 4.1.1.17 |
CATH/Gene3D | 3.20.20.10, 2.40.37.10 |
ChEMBL Target | CHEMBL1869 (Hs), CHEMBL2840 (Mm), CHEMBL3511 (Rn) |
Ensembl Gene | ENSG00000115758 (Hs), ENSMUSG00000011179 (Mm), ENSRNOG00000005424 (Rn) |
Entrez Gene | 4953 (Hs), 18263 (Mm), 24609 (Rn) |
Human Protein Atlas | ENSG00000115758 (Hs) |
KEGG Enzyme | 4.1.1.17 |
KEGG Gene | hsa:4953 (Hs), mmu:18263 (Mm), rno:24609 (Rn) |
OMIM | 165640 (Hs) |
Pharos | P11926 (Hs) |
UniProtKB | P11926 (Hs), P00860 (Mm), P09057 (Rn) |
Wikipedia | ODC1 (Hs) |
Selected 3D Structures | |||||||||||
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Enzyme Reaction | ||||
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Substrates and Reaction Kinetics | ||||||||||||||||||||||||
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Cofactors | ||||||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Clinically-Relevant Mutations and Pathophysiology | ||||||||||||||
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1. Almrud JJ, Oliveira MA, Kern AD, Grishin NV, Phillips MA, Hackert ML. (2000) Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding. J Mol Biol, 295 (1): 7-16. [PMID:10623504]
2. Qu N, Ignatenko NA, Yamauchi P, Stringer DE, Levenson C, Shannon P, Perrin S, Gerner EW. (2003) Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. Biochem J, 375 (Pt 2): 465-70. [PMID:12859253]
3. Stanek J, Frei J, Mett H, Schneider P, Regenass U. (1992) 2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem, 35 (8): 1339-44. [PMID:1573631]
4. Zell JA, Ziogas A, Ignatenko N, Honda J, Qu N, Bobbs AS, Neuhausen SL, Gerner EW, Anton-Culver H. (2009) Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. Clin Cancer Res, 15 (19): 6208-16. [PMID:19789310]
Decarboxylases: Ornithine decarboxylase. Last modified on 16/04/2015. Accessed on 06/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1276.