Organic anion transporters (OATs) | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC superfamily of solute carriers
SLC22 family of organic cation and anion transporters
Organic anion transporters (OATs)

Organic anion transporters (OATs) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Organic anion transporters (OATs) are non-selective transporters prominent in the kidney, placenta and blood-brain barrier.

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

OAT1 (Organic anion transporter 1 / SLC22A6) C Show summary »« Hide summary More detailed page

Target Id

1025

Nomenclature

Organic anion transporter 1

Systematic nomenclature

SLC22A6

Common abbreviation

OAT1

Previous and unofficial names

Genes

SLC22A6 (Hs), Slc22a6 (Mm), Slc22a6 (Rn)

Ensembl ID

ENSG00000197901 (Hs), ENSMUSG00000024650 (Mm), ENSRNOG00000018215 (Rn)

UniProtKB AC

Q4U2R8 (Hs), Q8VC69 (Mm), O35956 (Rn)

Bioparadigms SLC Tables

SLC22A6 (Hs)

Substrates

aminohippuric acid

non-steroidal anti-inflammatory drugs

Inhibitors

probenecid pIC₅₀ 4.9 (Inhibition of urate transport by human SCL22A6.) [2]

Stoichiometry

Unknown

OAT2 (Organic anion transporter 2 / SLC22A7) C Show summary »« Hide summary

Target Id

1026

Nomenclature

Organic anion transporter 2

Systematic nomenclature

SLC22A7

Common abbreviation

OAT2

Previous and unofficial names

Novel liver transporter | NLT | solute carrier family 22 member 7 | solute carrier family 22 (organic anion transporter), member 7 | solute carrier family 22 (organic anion transporter)

Genes

SLC22A7 (Hs), Slc22a7 (Mm), Slc22a7 (Rn)

Ensembl ID

ENSG00000137204 (Hs), ENSMUSG00000067144 (Mm), ENSRNOG00000018420 (Rn)

UniProtKB AC

Q9Y694 (Hs), Q91WU2 (Mm), Q5RLM2 (Rn)

Bioparadigms SLC Tables

SLC22A7 (Hs)

Substrates

PGE₂

aminohippuric acid

non-steroidal anti-inflammatory drugs

Stoichiometry

Unknown

OAT3 (Organic anion transporter 3 / SLC22A8) C Show summary »« Hide summary More detailed page

Organic anion transporter 4 / SLC22A11 C Show summary »« Hide summary More detailed page

OAT5 (Organic anion transporter 5 / SLC22A10) C Show summary »« Hide summary

Target Id

1029

Nomenclature

Organic anion transporter 5

Systematic nomenclature

SLC22A10

Common abbreviation

OAT5

Previous and unofficial names

solute carrier family 22 (organic anion/cation transporter), member 10 | solute carrier family 22, member 10

Genes

SLC22A10 (Hs)

Ensembl ID

ENSG00000184999 (Hs)

UniProtKB AC

Q63ZE4 (Hs)

Bioparadigms SLC Tables

SLC22A10 (Hs)

Substrates

ochratoxin A [5]

Stoichiometry

Unknown

OAT4 (Organic anion transporter 7 / SLC22A9) C Show summary »« Hide summary

Target Id	1028
Nomenclature	Organic anion transporter 7
Systematic nomenclature	SLC22A9
Common abbreviation	OAT4
Previous and unofficial names	UST3 \| OAT7 \| integral membrane transport protein UST4r \| solute carrier family 22 (organic anion transporter), member 9 \| solute carrier family 22, member 30 \| solute carrier family 22
Genes	SLC22A9 (Hs), Slc22a30 (Mm), UST4r (Rn)
Ensembl ID	ENSG00000149742 (Hs), ENSMUSG00000052562 (Mm), ENSRNOG00000029998 (Rn)
UniProtKB AC	Q8IVM8 (Hs)
Bioparadigms SLC Tables	SLC22A9 (Hs)
Stoichiometry	Unknown

References

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1. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H. (2000) Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J. Biol. Chem., 275 (6): 4507-12. [PMID:10660625]

2. Ichida K, Hosoyamada M, Kimura H, Takeda M, Utsunomiya Y, Hosoya T, Endou H. (2003) Urate transport via human PAH transporter hOAT1 and its gene structure. Kidney Int., 63 (1): 143-55. [PMID:12472777]

3. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H. (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J. Biol. Chem., 274 (19): 13675-80. [PMID:10224140]

4. Nigam SK, Bhatnagar V. (2018) The systems biology of uric acid transporters: the role of remote sensing and signaling. Curr. Opin. Nephrol. Hypertens., 27 (4): 305-313. [PMID:29847376]

5. Youngblood GL, Sweet DH. (2004) Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Am. J. Physiol. Renal Physiol., 287 (2): F236-44. [PMID:15068970]

NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.