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Organic zwitterions/cation transporters (OCTN) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Organic zwitterions/cation transporters (OCTN) function as organic cation uniporters, organic cation/proton exchangers or sodium/L-carnitine co-transporters.

Transporters

1022
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Targets of relevance to immunopharmacology are highlighted in blue

OCTN1 (Organic cation/carnitine transporter 1 / SLC22A4) C Show summary »

Target Id 1022
Nomenclature Organic cation/carnitine transporter 1
Systematic nomenclature SLC22A4
Common abbreviation OCTN1
Previous and unofficial names Ergothioneine transporter | ET | solute carrier family 22 (organic cation/ergothioneine transporter), member 4 | solute carrier family 22 (organic cation transporter), member 4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | solute carrier family 22 (organic cation transporter)
Genes SLC22A4 (Hs), Slc22a4 (Mm), Slc22a4 (Rn)
Ensembl ID ENSG00000197208 (Hs), ENSMUSG00000020334 (Mm), ENSRNOG00000046195 (Rn)
UniProtKB AC Q9H015 (Hs), Q9Z306 (Mm), Q9R141 (Rn)
Bioparadigms SLC Tables SLC22A4 (Hs)
RESOLUTE SLC22A4 (Hs)
Endogenous substrates
L-carnitine
Substrates
mepyramine
tetraethylammonium
verapamil
MPP+
Stoichiometry Unknown

OCTN2 (Organic cation/carnitine transporter 2 / SLC22A5) C Show summary »

CT2 (Carnitine transporter 2 / SLC22A16) C Show summary »

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.