sovateltide   Click here for help

GtoPdb Ligand ID: 3886

Synonyms: IRL 1620 | IRL-1620 | IRL2620 | PMZ-1620 | SPI-1620 | Suc[Glu9,Ala11,15]ET-110-21 | Tycamzzi®
Approved drug
sovateltide is an approved drug (India CDSCO (2023))
Compound class: Peptide
Comment: Sovateltide (previously IRL-1620 and PMZ-1620) is a selective endothelin-B receptor (ETB) agonist. It is proposed as a mechanism to improve formation of new mature neurons and blood vessels in acute cerebral ischemia [1].
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2D Structure
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SMILES / InChI / InChIKey
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Canonical SMILES CCC(C(C(=O)NC(C(=O)NC(C(=O)O)Cc1c[nH]c2c1cccc2)C(CC)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CCC(=O)O)CC(=O)O)CCC(=O)O)CCC(=O)O)C)Cc1ccc(cc1)O)Cc1ccccc1)C)Cc1nc[nH]c1)CC(C)C)CC(=O)O)C
Isomeric SMILES CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCC(=O)O)CC(=O)O)CCC(=O)O)CCC(=O)O)C)Cc1ccc(cc1)O)Cc1ccccc1)C)Cc1nc[nH]c1)CC(C)C)CC(=O)O)C
InChI InChI=1S/C86H117N17O27/c1-11-44(7)71(84(127)100-63(86(129)130)35-50-39-88-54-21-17-16-20-53(50)54)103-85(128)72(45(8)12-2)102-82(125)62(38-69(114)115)98-78(121)57(32-42(3)4)96-80(123)60(36-51-40-87-41-89-51)95-73(116)46(9)91-77(120)58(33-48-18-14-13-15-19-48)97-79(122)59(34-49-22-24-52(104)25-23-49)99-83(126)70(43(5)6)101-74(117)47(10)90-75(118)55(26-29-65(106)107)93-76(119)56(27-30-66(108)109)94-81(124)61(37-68(112)113)92-64(105)28-31-67(110)111/h13-25,39-47,55-63,70-72,88,104H,11-12,26-38H2,1-10H3,(H,87,89)(H,90,118)(H,91,120)(H,92,105)(H,93,119)(H,94,124)(H,95,116)(H,96,123)(H,97,122)(H,98,121)(H,99,126)(H,100,127)(H,101,117)(H,102,125)(H,103,128)(H,106,107)(H,108,109)(H,110,111)(H,112,113)(H,114,115)(H,129,130)/t44-,45-,46-,47-,55-,56-,57-,58-,59-,60-,61-,62-,63-,70-,71-,72-/m0/s1
InChI Key DXPHNGAMYPPTBJ-TZMIJSMNSA-N
Classification Click here for help
Compound class Peptide
Approved drug? Yes (India CDSCO (2023))
International Nonproprietary Names Click here for help
INN number INN
11139 sovateltide
Synonyms Click here for help
IRL 1620 | IRL-1620 | IRL2620 | PMZ-1620 | SPI-1620 | Suc[Glu9,Ala11,15]ET-110-21 | Tycamzzi®
Database Links Click here for help
Specialist databases
GPCRdb Ligand sovateltide
Other databases
CAS Registry No. 142569-99-1 (source: Scifinder)
ChEMBL Ligand CHEMBL3188091
GtoPdb PubChem SID 178100722
PubChem CID 16133819
Search Google for chemical match using the InChIKey DXPHNGAMYPPTBJ-TZMIJSMNSA-N
Search Google for chemicals with the same backbone DXPHNGAMYPPTBJ
Search PubMed clinical trials sovateltide
Search PubMed titles sovateltide
Search PubMed titles/abstracts sovateltide
UniChem Compound Search for chemical match using the InChIKey DXPHNGAMYPPTBJ-TZMIJSMNSA-N
UniChem Connectivity Search for chemical match using the InChIKey DXPHNGAMYPPTBJ-TZMIJSMNSA-N

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Tocris
IRL-1620 (links to external site)
Cat. No. 1196