Synonyms: CD-NP
Compound class:
Peptide or derivative
Comment: Cenderitide is a designed chimeric natriuretic peptide (NP) engineered to co-activate the two known NP receptors, guanylyl cyclase (GC) -A and -B [1]. It comprises the sequence for C-type natriuretic peptide at the N-terminus (residues 1-22) joined to 15 amino acids (23-37) of the C-terminus of Dendroaspis natriuretic peptide (DNP), isolated from the venom of the green Mamba snake Dendroaspis angusticeps. Synthetic DNP has useful renal activity [2]. Cenderitide combines the beneficial vascular and antiproliferative properties of CNP with the potent natriuretic and diuretic hypotensive effects of DNP.
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Peptide Sequence | |
GLSKGCFGLKLDRIGSMSGLGCPSLRDPRPDAPSTSA | |
Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Pro-Ser-Leu-Arg-Asp-Pro-Arg-Pro-Asp-Ala-Pro-Ser-Thr-Ser-Ala |
Download 2D Structure | |
Canonical SMILES | Download |
Isomeric SMILES | Download |
InChI standard identifier | Download |
InChI standard key | Download |
Molecular structure representations generated using Open Babel