tolyacetyl-c[DCys-Apa-DTrp-Orn-Val-Cys]-His-amide   Click here for help

GtoPdb Ligand ID: 2166

Compound class: Peptide or derivative
Comment: This synthetic peptide is an analogue of the conserved cyclic hexapeptide portion of urotensin-II (amino acids 5-10 of the endogenous peptide). A histidine replaces the valine in the carboxy terminal position 11 of the natural ligand.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Peptide Sequence Click here for help
CXWXVCH
Cys-Apa-Trp-Orn-Val-Cys-His
Chemical Modification
The amino terminal is tolacetylated and the carboxy terminal is amidated. Cys1 and Trp3 are D-amino acids, X2 is Apa (3-aminopropionic acid) and X4 is Orn (ornithine). The peptide is cyclic with a disulphide bond forming between the Cys residues.