Tri-DAP

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Ligands
Tri-DAP

GtoPdb Ligand ID: 9507

Synonyms: L-Ala-γ-D-Glu-mDAP

Comment: Tri-DAP comprises the γ-iE-DAP (γ-D-Glu-mDAP) dipeptide and a L-Ala residue. It is an agonist of the NOD1 pattern recognition receptor.

References
1. Lee J, Tattoli I, Wojtal KA, Vavricka SR, Philpott DJ, Girardin SE. (2009) pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem, 284 (35): 23818-29. [PMID:19570976]
2. Sasawatari S, Okamura T, Kasumi E, Tanaka-Furuyama K, Yanobu-Takanashi R, Shirasawa S, Kato N, Toyama-Sorimachi N. (2011) The solute carrier family 15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice. Gastroenterology, 140 (5): 1513-25. [PMID:21277849]
3. Song F, Hu Y, Wang Y, Smith DE, Jiang H. (2018) Functional Characterization of Human Peptide/Histidine Transporter 1 in Stably Transfected MDCK Cells. Mol Pharm, 15 (2): 385-393. [PMID:29224352]
4. Wang Y, Hu Y, Li P, Weng Y, Kamada N, Jiang H, Smith DE. (2018) Expression and regulation of proton-coupled oligopeptide transporters in colonic tissue and immune cells of mice. Biochem Pharmacol, 148: 163-173. [PMID:29305856]

References

1. Lee J, Tattoli I, Wojtal KA, Vavricka SR, Philpott DJ, Girardin SE. (2009)
pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling.
J Biol Chem, 284 (35): 23818-29. [PMID:19570976]

2. Sasawatari S, Okamura T, Kasumi E, Tanaka-Furuyama K, Yanobu-Takanashi R, Shirasawa S, Kato N, Toyama-Sorimachi N. (2011)
The solute carrier family 15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice.
Gastroenterology, 140 (5): 1513-25. [PMID:21277849]

3. Song F, Hu Y, Wang Y, Smith DE, Jiang H. (2018)
Functional Characterization of Human Peptide/Histidine Transporter 1 in Stably Transfected MDCK Cells.
Mol Pharm, 15 (2): 385-393. [PMID:29224352]

4. Wang Y, Hu Y, Li P, Weng Y, Kamada N, Jiang H, Smith DE. (2018)
Expression and regulation of proton-coupled oligopeptide transporters in colonic tissue and immune cells of mice.
Biochem Pharmacol, 148: 163-173. [PMID:29305856]