L-methionine   Click here for help

GtoPdb Ligand ID: 4814

Abbreviated name: L-Met
PDB Ligand
Compound class: Metabolite
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 88.62
Molecular weight 149.05
XLogP -1.85
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CSCCC(C(=O)O)N
Isomeric SMILES CSCC[C@@H](C(=O)O)N
InChI InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChI Key FFEARJCKVFRZRR-BYPYZUCNSA-N
References
1. Albers A, Bröer A, Wagner CA, Setiawan I, Lang PA, Kranz EU, Lang F, Bröer S. (2001)
Na+ transport by the neural glutamine transporter ATA1.
Pflugers Arch, 443 (1): 92-101. [PMID:11692272]
2. Babu E, Kanai Y, Chairoungdua A, Kim DK, Iribe Y, Tangtrongsup S, Jutabha P, Li Y, Ahmed N, Sakamoto S et al.. (2003)
Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters.
J Biol Chem, 278 (44): 43838-45. [PMID:12930836]
3. Bröer S. (2006)
The SLC6 orphans are forming a family of amino acid transporters.
Neurochem Int, 48 (6-7): 559-67. [PMID:16540203]
4. Hatanaka T, Huang W, Wang H, Sugawara M, Prasad PD, Leibach FH, Ganapathy V. (2000)
Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.
Biochim Biophys Acta, 1467 (1): 1-6. [PMID:10930503]
5. Sloan JL, Mager S. (1999)
Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+).
J Biol Chem, 274 (34): 23740-5. [PMID:10446133]
6. Vanslambrouck JM, Bröer A, Thavyogarajah T, Holst J, Bailey CG, Bröer S, Rasko JE. (2010)
Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria.
Biochem J, 428 (3): 397-407. [PMID:20377526]
7. Zaia KA, Reimer RJ. (2009)
Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport.
J Biol Chem, 284 (13): 8439-48. [PMID:19147495]