muscarinic toxin 3   Click here for help

GtoPdb Ligand ID: 313

Synonyms: mamba toxin-3 | MT3
Comment: MT3 (M4-toxin), like MT7 (M1-toxin), is a toxin from the venom of the Eastern green mamba (Dendroaspis augusticeps) [1,3,5].
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1. Bradley KN. (2000)
Muscarinic toxins from the green mamba.
Pharmacol Ther, 85 (2): 87-109. [PMID:10722122]
2. Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD. (2018)
Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro.
Invest Ophthalmol Vis Sci, 59 (7): 2778-2791. [PMID:29860464]
3. Jolkkonen M, van Giersbergen PL, Hellman U, Wernstedt C, Karlsson E. (1994)
A toxin from the green mamba Dendroaspis angusticeps: amino acid sequence and selectivity for muscarinic m4 receptors.
FEBS Lett, 352 (1): 91-4. [PMID:7925952]
4. Olianas MC, Ingianni A, Maullu C, Adem A, Karlsson E, Onali P. (1999)
Selectivity profile of muscarinic toxin 3 in functional assays of cloned and native receptors.
J Pharmacol Exp Ther, 288 (1): 164-70. [PMID:9862767]
5. Potter LT. (2001)
Snake toxins that bind specifically to individual subtypes of muscarinic receptors.
Life Sci, 68 (22-23): 2541-7. [PMID:11392624]