muscarinic toxin 3   Click here for help

GtoPdb Ligand ID: 313

Synonyms: mamba toxin-3 | MT3
Compound class: Peptide
Comment: MT3 (M4-toxin), like MT7 (M1-toxin), is a toxin from the venom of the Eastern green mamba (Dendroaspis augusticeps) [1,3,5].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Bradley KN. (2000)
Muscarinic toxins from the green mamba.
Pharmacol Ther, 85 (2): 87-109. [PMID:10722122]
2. Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD. (2018)
Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro.
Invest Ophthalmol Vis Sci, 59 (7): 2778-2791. [PMID:29860464]
3. Jolkkonen M, van Giersbergen PL, Hellman U, Wernstedt C, Karlsson E. (1994)
A toxin from the green mamba Dendroaspis angusticeps: amino acid sequence and selectivity for muscarinic m4 receptors.
FEBS Lett, 352 (1): 91-4. [PMID:7925952]
4. Olianas MC, Ingianni A, Maullu C, Adem A, Karlsson E, Onali P. (1999)
Selectivity profile of muscarinic toxin 3 in functional assays of cloned and native receptors.
J Pharmacol Exp Ther, 288 (1): 164-70. [PMID:9862767]
5. Potter LT. (2001)
Snake toxins that bind specifically to individual subtypes of muscarinic receptors.
Life Sci, 68 (22-23): 2541-7. [PMID:11392624]