Synonyms: 5,7,4'-trihydroxyisoflavone
Compound class:
Natural product
Comment: Genistein is a phytochemical present in soy extract that has antioxidant, anti-inflammatory, and estrogenic effects.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Bagheri M, Joghataei MT, Mohseni S, Roghani M. (2011)
Genistein ameliorates learning and memory deficits in amyloid β(1-40) rat model of Alzheimer's disease. Neurobiol Learn Mem, 95 (3): 270-6. [PMID:21144907] |
2. Kuiper GG, Carlsson B, Grandien K, Enmark E, Häggblad J, Nilsson S, Gustafsson JA. (1997)
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology, 138 (3): 863-70. [PMID:9048584] |
3. Nowak S, Di Pizio A, Levit A, Niv MY, Meyerhof W, Behrens M. (2018)
Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14. Biochim Biophys Acta Gen Subj, 1862 (10): 2162-2173. [PMID:30009876] |
4. Roland WS, Vincken JP, Gouka RJ, van Buren L, Gruppen H, Smit G. (2011)
Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39. J Agric Food Chem, 59 (21): 11764-71. [PMID:21942422] |
5. Sharma D, Singh V, Kumar A, Singh TG. (2025)
Genistein: A promising ally in combating neurodegenerative disorders. Eur J Pharmacol, 991: 177273. [PMID:39828018] |
6. Suetsugi M, Su L, Karlsberg K, Yuan YC, Chen S. (2003)
Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res, 1 (13): 981-91. [PMID:14638870] |
7. Verkman AS, Galietta LJ. (2009)
Chloride channels as drug targets. Nat Rev Drug Discov, 8 (2): 153-71. [PMID:19153558] |
8. Wong CO, Huang Y, Yao X. (2010)
Genistein potentiates activity of the cation channel TRPC5 independently of tyrosine kinases. Br J Pharmacol, 159 (7): 1486-96. [PMID:20233211] |