Ni2+   Click here for help

GtoPdb Ligand ID: 2476

Synonyms: nickel ion
Compound class: Inorganic
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Goytain A, Quamme GA. (2005)
Functional characterization of the mouse [corrected] solute carrier, SLC41A2.
Biochem Biophys Res Commun, 330 (3): 701-5. [PMID:15809054]
2. Kirichok Y, Lishko PV. (2011)
Rediscovering sperm ion channels with the patch-clamp technique.
Mol Hum Reprod, 17 (8): 478-99. [PMID:21642646]
3. Kirichok Y, Navarro B, Clapham DE. (2006)
Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel.
Nature, 439 (7077): 737-40. [PMID:16467839]
4. Lee JH, Gomora JC, Cribbs LL, Perez-Reyes E. (1999)
Nickel block of three cloned T-type calcium channels: low concentrations selectively block alpha1H.
Biophys J, 77 (6): 3034-42. [PMID:10585925]
5. Pelucchi B, Aguiari G, Pignatelli A, Manzati E, Witzgall R, Del Senno L, Belluzzi O. (2006)
Nonspecific cation current associated with native polycystin-2 in HEK-293 cells.
J Am Soc Nephrol, 17 (2): 388-97. [PMID:16396967]
6. Soong TW, Stea A, Hodson CD, Dubel SJ, Vincent SR, Snutch TP. (1993)
Structure and functional expression of a member of the low voltage-activated calcium channel family.
Science, 260 (5111): 1133-6. [PMID:8388125]
7. Williams ME, Marubio LM, Deal CR, Hans M, Brust PF, Philipson LH, Miller RJ, Johnson EC, Harpold MM, Ellis SB. (1994)
Structure and functional characterization of neuronal alpha 1E calcium channel subtypes.
J Biol Chem, 269 (35): 22347-57. [PMID:8071363]
8. Zamponi GW, Bourinet E, Snutch TP. (1996)
Nickel block of a family of neuronal calcium channels: subtype- and subunit-dependent action at multiple sites.
J Membr Biol, 151 (1): 77-90. [PMID:8661496]