Abbreviated name: DHEA
Synonyms: androstenolone | dehydroepiandrostenedione | DHA | Intrarosa® | Prasterone
dehydroepiandrosterone is an approved drug (FDA (2016), EMA (2018))
Compound class:
Metabolite or derivative
Comment: Dehydroepiandrosterone (DHEA; prasterone) is a precursor that is converted to oestrogens and androgens.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Maksay G, Laube B, Betz H. (2001)
Subunit-specific modulation of glycine receptors by neurosteroids. Neuropharmacology, 41 (3): 369-76. [PMID:11522328] |
2. Rose KA, Stapleton G, Dott K, Kieny MP, Best R, Schwarz M, Russell DW, Björkhem I, Seckl J, Lathe R. (1997)
Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone. Proc Natl Acad Sci USA, 94 (10): 4925-30. [PMID:9144166] |