mutant ANP

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Ligands
mutant ANP

GtoPdb Ligand ID: 10211

Synonyms: mANP | mutant atrial natriuretic peptide

Compound class: Peptide or derivative

Comment: This is a naturally occurring variant of human atrial natriuretic peptide (ANP) [1]. It is a fusion protein that contains the full 28 amino acids of ANP plus a 12 amino acid C-terminal extension. In comparison to normal ANP this longer peptide exhibits enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions in vivo.

References
1. Hodgson-Zingman DM, Karst ML, Zingman LV, Heublein DM, Darbar D, Herron KJ, Ballew JD, de Andrade M, Burnett Jr JC, Olson TM. (2008) Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation. N Engl J Med, 359 (2): 158-65. [PMID:18614783]
2. McKie PM, Cataliotti A, Huntley BK, Martin FL, Olson TM, Burnett Jr JC. (2009) A human atrial natriuretic peptide gene mutation reveals a novel peptide with enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions. J Am Coll Cardiol, 54 (11): 1024-32. [PMID:19729120]

References

1. Hodgson-Zingman DM, Karst ML, Zingman LV, Heublein DM, Darbar D, Herron KJ, Ballew JD, de Andrade M, Burnett Jr JC, Olson TM. (2008)
Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation.
N Engl J Med, 359 (2): 158-65. [PMID:18614783]

2. McKie PM, Cataliotti A, Huntley BK, Martin FL, Olson TM, Burnett Jr JC. (2009)
A human atrial natriuretic peptide gene mutation reveals a novel peptide with enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions.
J Am Coll Cardiol, 54 (11): 1024-32. [PMID:19729120]