(-)-noradrenaline   Click here for help

GtoPdb Ligand ID: 505

Synonyms: (-)-norepinephrine | Levarterenol® | noradrenaline
Approved drug PDB Ligand
(-)-noradrenaline is an approved drug (FDA (1950))
Compound class: Metabolite
Comment: Marketed formulations may contain noradrenaline tartrate (PubChem CID 25127519).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 86.71
Molecular weight 169.07
XLogP -0.11
No. Lipinski's rules broken 0
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Canonical SMILES NCC(c1ccc(c(c1)O)O)O
Isomeric SMILES NC[C@@H](c1ccc(c(c1)O)O)O
InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
No information available.
Summary of Clinical Use Click here for help
Used in the treatment of vasodilatory shock states such as septic shock and neurogenic shock. Also used in the treatment of critical hypotension as a vasopressor medication.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Agonism of alpha-1 and alpha-2 adrenergic receptors leads to peripheral vasoconstriction. Activity at beta-adrenergic receptors leads to dilation of the coronary arteries.
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