abicipar pegol   Click here for help

GtoPdb Ligand ID: 8371

Synonyms: AGN-150998 | MP0112
Compound class: Peptide or derivative
Comment: Abicipar pegol is a VEGFA targeting protein conjugate generated using DARPin® technology [1,3]. The INN record for this construct describes it as a 'pegylated composite protein for clinical applications (CPCA)'. The amino acid sequence for the protein component is provided here. Structurally, the conjugate contains glycyl-seryl-ankyrin repeats (3-35, 36-68, 69-101, 102-123) with a short linker (127-134) and a cysteine di-sulphide bond (1-135), conjugated via a maleimide group linker (thioether bond to C135) to a single linear methoxy polyethylene glycol 20 (mPEG20). DARPins are protein therapeutics that are being developed as an alternative to antigen receptors (antibodies).
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
VEGFA Primary target of this compound Hs Inhibitor Inhibition 11.7 pKd - 2
⤷ pKd 11.7 (Kd 2x10-12 M) [2]