Synonyms: INOmax® | nitric oxide | nitrogen monoxide
NO is an approved drug (FDA (1999), EMA (2001))
Compound class:
Inorganic
Comment: Nitric oxide is a free radical and an important cellular signaling molecule involved in many physiological and pathological processes. The drugs nitroglycerin and amyl nitrite are nitric oxide precursors.
View more information in the IUPHAR Pharmacology Education Project: nitric oxide |
Enzymes Catalysing Reactions with this Compound as a Substrate or Product | ||||||||||||||||
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Selectivity at ion channels | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Selectivity at catalytic receptors | ||||||||||||||||||||||||||||||||||
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Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Endogenous inhibitors at adenylyl cyclase 6 | Gαi, Ca2+, PKA-evoked phosphorylation, PKC-evoked phosphorylation, NO | 1,5,8-10 |
Endogenous inhibitors at adenylyl cyclase 5 | Gαi, Ca2+, PKA-evoked phosphorylation, Gβγ, NO | 3,5-7,9 |
Endogenous ligand(s) at Guanylyl cyclase, α2β1 | NO | |
Endogenous ligand(s) at Guanylyl cyclase, α1β1 | NO |
Other ligands which bind to or alter the activity of this ligand | ||||||||||||||||||||||||||||||||||||||||||||||
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Ligand mentioned in the following text fields |
Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase overview |