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GtoPdb Ligand ID: 2356

Synonyms: cesium cation | cesium ion
Compound class: Inorganic
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kir4.1 Rn Channel blocker Antagonist - - 3x10-5 - 3x10-4 15
⤷ Conc range: 3x10-5 - 3x10-4 M [15]
Voltage: -160.0 – 50.0 mV
Kir4.2 Mm Channel blocker Antagonist - - 1x10-5 - 1x10-4 12
⤷ Conc range: 1x10-5 - 1x10-4 M Kir4.2 expressed in Xenopus oocytes [12]
Voltage: -120.0 – 100.0 mV
Kir2.2 Mm Gating inhibitor Antagonist - - 5x10-6 - 5x10-5 14
⤷ Conc range: 5x10-6 - 5x10-5 M [14]
Voltage: -150.0 – -50.0 mV
Kir2.4 Hs Channel blocker Antagonist 3.0 – 4.1 pKd - 5
⤷ pKd 3.0 – 4.1 [5]
Voltage: -60.0 – -100.0 mV
Kir2.1 Mm Channel blocker Antagonist 1.3 – 4.0 pKd 3x10-5 - 3x10-4 1
⤷ pKd 1.3 – 4.0 Conc range: 3x10-5 - 3x10-4 M [1]
Voltage: 0.0 – -102.0 mV
Kv12.2 Hs Channel blocker Pore blocker 1.2 pKd - 2
⤷ pKd 1.2 [2]
Kir2.3 Hs Channel blocker Antagonist 1.3 – 4.5 pKi 3x10-6 - 3x10-4 9
⤷ pKi 1.3 – 4.5 Conc range: 3x10-6 - 3x10-4 M [9]
Voltage: 0.0 – -130.0 mV
Kir2.4 Rn Channel blocker Antagonist 2.1 pKi - 16
⤷ pKi 2.1 [16]
Voltage: -80.0 mV
Kir7.1 Hs Channel blocker Antagonist 1.6 pKi - 4,7,11
⤷ pKi 1.6 [4,7,11]
Voltage: -100.0 mV
Kir3.4 Rn Channel blocker Antagonist 4.0 pEC50 - 6
⤷ pEC50 4.0 [6]
Voltage: -80.0 mV
Kir2.3 Mm Channel blocker Antagonist 5.0 pIC50 5x10-6 - 5x10-4 8,10
⤷ pIC50 5.0 Conc range: 5x10-6 - 5x10-4 M [8,10]
Voltage: -150.0 mV
HCN3 Hs Channel blocker Antagonist 3.8 pIC50 - 13
⤷ pIC50 3.8 (IC50 1.57x10-4 M) [13]
Voltage: -40.0 mV
HCN4 Hs Channel blocker Antagonist 3.8 pIC50 - 13
⤷ pIC50 3.8 (IC50 1.75x10-7 M) [13]
Voltage: -40.0 mV
HCN1 Hs Channel blocker Antagonist 3.7 pIC50 - 13
⤷ pIC50 3.7 (IC50 2.01x10-7 M) [13]
Voltage: -40.0 mV
HCN2 Hs Channel blocker Antagonist 3.7 pIC50 - 13
⤷ pIC50 3.7 (IC50 2.06x10-7 M) [13]
Voltage: -40.0 mV
Kir1.1 Rn Channel blocker Antagonist 2.9 pIC50 - 17
⤷ pIC50 2.9 [17]
Voltage: -120.0 mV
Kir5.1 Rn Channel blocker Antagonist - - - 3
⤷ [3]
Voltage: Physiological