imaprelimab   Click here for help

GtoPdb Ligand ID: 9805

Synonyms: PRX-003 | PRX003
Immunopharmacology Ligand
Compound class: Antibody
Comment: Imaprelimab (PRX-003) is an anti-MCAM mAb developed as a novel therapy for psoriasis. In patients with autoimmune diseases, a subset of MCAM+ve T cells (which have an effector memory T-helper 17 phenotype) produce high levels of pro-inflammatory IL-17 [1,3]. Pharmacological disruption of MCAM function is thought to be a valid mechanism for the treatment of autoimmune inflammation. Peptide sequence alignments identify imaprelimab as one of the preferred antibodies claimed in patent WO2014039975 [2] (SEQ IDs 119 and 123 match the sequences submitted to the WHO for INN imaprelimab). These peptide sequences map to the construct identified as h2120VH5/L3.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
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Summary of Clinical Use Click here for help
PRX-003 was being evaluated in Phase 1 clinical trial NCT02630901 in patients with psoriasis. However, the drug failed to meet primary or secondary endpoints, so development has been terminated (see Prothena's press release).
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT02630901 Multiple Ascending Dose Study of PRX003 in Subjects With Psoriasis Phase 1 Interventional Prothena Biosciences Limited