onfekafusp alfa   Click here for help

GtoPdb Ligand ID: 9757

Synonyms: Daramun (bifikafusp alfa and onfekafusp alfa) | Fibronum | L19TNF-alpha | Nidlegy (bifikafusp alfa and onfekafusp alfa)
Immunopharmacology Ligand
Compound class: Antibody
Comment: Onfekafusp alfa (Fibromun; L19-TNF) is a trimeric homodimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF [1]. LIke bifikafusp alfa, Fibromun targets the TNF to the tumour microenvironment via L19 binding to the angiogenesis-associated isoform of fibronectin (specifically the extradomain B or EDB). Fibromun is being investigated as an immuno-oncology therapeutic. It is one of a growing number of so-called 'immunocytokines' entering clinical development.
No information available.
Summary of Clinical Use Click here for help
A combination of fibronum with the similarly designed L19-IL2 diabody bifikafusp alfa is in Phase 3 clinical trial NCT02938299 for malignamt melanoma (Phase 2 results published in [2]).
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT02938299 Neoadjuvant L19IL2/L19TNF- Pivotal Study Phase 3 Interventional Philogen S.p.A.