BI-6901   

GtoPdb Ligand ID: 9714

Abbreviated name: BI 6901
Synonyms: BI 6901 | BI6901 | eut-22 [1]
Compound class: Synthetic organic
Comment: BI-6901 is a selective inhibitor of the chemokine receptor CCR10 [1]. This chemical structure is the active enantiomer (or eutomer) of the compound. The CCL27-CCR10 axis is a molecular target for the development of novel therapies for inflammatory skin conditions.
This ligand is one of the compounds available from Boehringer Ingelheim's opnMe molecular library.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 119.37
Molecular weight 453.18
XLogP 2.82
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES N#Cc1cccn1CCC(C(=O)N1CCC(CC1)C)NS(=O)(=O)c1cccc2c1cc[nH]2
Isomeric SMILES N#Cc1cccn1CC[C@H](C(=O)N1CCC(CC1)C)NS(=O)(=O)c1cccc2c1cc[nH]2
InChI InChI=1S/C23H27N5O3S/c1-17-8-13-28(14-9-17)23(29)21(10-15-27-12-3-4-18(27)16-24)26-32(30,31)22-6-2-5-20-19(22)7-11-25-20/h2-7,11-12,17,21,25-26H,8-10,13-15H2,1H3/t21-/m1/s1
InChI Key BRJXJOWXAFLRTE-OAQYLSRUSA-N
Classification
Compound class Synthetic organic
IUPAC Name
4-(2-cyano-1H-pyrrol-1-yl)-S-(1H-indol-4-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutane-2-sulfonamido
Synonyms
BI 6901 | BI6901 | eut-22 [1]
Database Links
GtoPdb PubChem SID 348353673
PubChem CID 131801164
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